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Descriptor English: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
Descriptor Spanish: 4,5-dihidro-1-(3-(trifluorometil)fenil)-1H-pirazol-3-amina
Descriptor Portuguese: 4,5-Di-Hidro-1-(3-(Trifluormetil)Fenil)-1H-Pirazol-3-Amina
Descriptor French: 1-(3-(Trifluorométhyl)phényl)-4,5-dihydro-1H-pyrazol-3-amine
Entry term(s): BW 755C
BW-755C
BW755C
Tree number(s): D03.383.129.539.180
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015772
Scope note: A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Inflammatory Agents, Non-Steroidal
Lipoxygenase Inhibitors
Cyclooxygenase Inhibitors
Registry Number: 66000-40-6
CAS Type 1 Name: 1H-Pyrazol-3-amine, 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)-
Previous Indexing: Anti-Inflammatory Agents (1966-1986)
Anti-Inflammatory Agents, Non-Steroidal (1987-1989)
Pyrazoles (1966-1989)
Public MeSH Note: 2005; see BW-775C 1996-2004; see BW 755C 1990; see BW-755C 1990-1995
History Note: 2005(1991)
DeCS ID: 29238
Unique ID: D015772
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2018/06/30
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - Preferred
Concept UI M0373905
Scope note A dual inhibitor of both cyclooxygenase and lipoxygenase pathways. It exerts an anti-inflammatory effect by inhibiting the formation of prostaglandins and leukotrienes. The drug also enhances pulmonary hypoxic vasoconstriction and has a protective effect after myocardial ischemia.
Preferred term 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
BW-755C - Narrower
Concept UI M0024166
Preferred term BW-755C
Entry term(s) BW 755C
BW755C



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