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Descriptor English: Valproic Acid
Descriptor Spanish: Ácido Valproico
Descriptor ácido valproico
Entry term(s) dipropil acetato
divalproex
valproato sódico
Scope note: Ácido graso con propiedades anticonvulsivas y antimaníacas utilizado en el tratamiento de la EPILEPSIA y del TRASTORNO BIPOLAR. No se conocen bien los mecanismos de sus acciones terapéuticas. Puede actuar aumentando las concentraciones de ÁCIDO GAMMA-AMINOBUTÍRICO en el encéfalo o alterando las propiedades de los CANALES DEL SODIO DEPENDIENTES DE VOLTAJE.
Descriptor Portuguese: Ácido Valproico
Descriptor French: Acide valproïque
Entry term(s): 2 Propylpentanoic Acid
2-Propylpentanoic Acid
Calcium Valproate
Convulsofin
Depakene
Depakine
Depakote
Dipropyl Acetate
Divalproex
Divalproex Sodium
Ergenyl
Magnesium Valproate
Propylisopropylacetic Acid
Semisodium Valproate
Sodium Valproate
Valproate
Valproate Calcium
Valproate Sodium
Valproic Acid, Sodium Salt (2:1)
Vupral
Tree number(s): D02.241.081.944.509.900
D10.251.400.895.593.900
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014635
Scope note: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticonvulsants
Enzyme Inhibitors
GABA Agents
Antimanic Agents
Registry Number: 614OI1Z5WI
CAS Type 1 Name: Pentanoic acid, 2-propyl-
Previous Indexing: Valerates (1966-1974)
Public MeSH Note: 1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
Online Note: use VALPROIC ACID to search VALPROATE 1979-90 & DIPROPYL ACETATE 1975-90
History Note: 1991; was VALPROATE 1979-1990; was DIPROPYL ACETATE see under VALERATES 1975-1978
DeCS ID: 29291
Unique ID: D014635
NLM Classification: QV 85
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1979/01/01
Date of Entry: 1974/11/11
Revision Date: 2018/06/19
Valproic Acid - Preferred
Concept UI M0022501
Scope note A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
Preferred term Valproic Acid
Entry term(s) 2 Propylpentanoic Acid
2-Propylpentanoic Acid
Divalproex
Depakene - Narrower
Concept UI M0351580
Preferred term Depakene
Convulsofin - Narrower
Concept UI M0351581
Preferred term Convulsofin
Depakote - Narrower
Concept UI M0351577
Preferred term Depakote
Dipropyl Acetate - Related but not broader or narrower
Concept UI M0022503
Preferred term Dipropyl Acetate
Divalproex Sodium - Narrower
Concept UI M0329594
Preferred term Divalproex Sodium
Entry term(s) Semisodium Valproate
Vupral - Narrower
Concept UI M0351578
Preferred term Vupral
Valproic Acid, Sodium Salt (2:1) - Narrower
Concept UI M000642454
Preferred term Valproic Acid, Sodium Salt (2:1)
Propylisopropylacetic Acid - Related but not broader or narrower
Concept UI M000642455
Preferred term Propylisopropylacetic Acid
Ergenyl - Narrower
Concept UI M0351579
Preferred term Ergenyl
Magnesium Valproate - Narrower
Concept UI M0022505
Preferred term Magnesium Valproate
Valproate - Narrower
Concept UI M0022502
Preferred term Valproate
Valproate Sodium - Narrower
Concept UI M0022500
Preferred term Valproate Sodium
Entry term(s) Sodium Valproate
Calcium Valproate - Narrower
Concept UI M0022499
Preferred term Calcium Valproate
Entry term(s) Valproate Calcium
Depakine - Narrower
Concept UI M000642453
Preferred term Depakine



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