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Descriptor English: Interferon-gamma
Descriptor Spanish: Interferón gamma
Descriptor interferón gamma
Entry term(s) interferón inmunitario
Scope note: El principal interferón producido por LINFOCITOS estimulados mitogénica o antigénicamente. Es estructuralmente diferente del INTERFERÓN TIPO I y su principal actividad es la inmunorregulación. Se ha relacionado con la expresión de ANTÍGENOS DE HISTOCOMPATIBILIDAD DE CLASE II en células que normalmente no los producen, dando lugar a ENFERMEDADES AUTOINMUNES.
Descriptor Portuguese: Interferon gama
Descriptor French: Interféron gamma
Entry term(s): Immune Interferon
Interferon Type II
Interferon, Immune
Interferon, Type II
Interferon, gamma
Type II Interferon
gamma-Interferon
Tree number(s): D12.644.276.374.440.893
D12.644.276.374.480.615.350
D12.776.467.374.440.893
D12.776.467.374.480.615.350
D23.529.374.440.893
D23.529.374.480.615.350
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007371
Scope note: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Antiviral Agents
Registry Number: 82115-62-6
CAS Type 1 Name: Interferon gamma (human lymphocyte protein moiety reduced)
Previous Indexing: Interferons (1966-1982)
Public MeSH Note: 2009; see INTERFERON TYPE II 1984-2008, see INTERFERON, GAMMA 1983-1990
History Note: 2009(1983); INTERFERON-GAMMA was INTERFERON, GAMMA 1983-1990
Related: Interferon-gamma Release Tests MeSH
DeCS ID: 29484
Unique ID: D007371
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1983/01/01
Date of Entry: 1982/05/19
Revision Date: 2015/06/22
Interferon-gamma - Preferred
Concept UI M0011490
Scope note The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Preferred term Interferon-gamma
Entry term(s) Immune Interferon
Interferon Type II
Interferon, Immune
Interferon, Type II
Interferon, gamma
Type II Interferon
gamma-Interferon



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