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Descriptor English: Primary Ovarian Insufficiency
Descriptor Spanish: Insuficiencia Ovárica Primaria
Descriptor insuficiencia ovárica primaria
Entry term(s) insuficiencia ovárica prematura
síndrome del ovario resistente
síndrome del ovario resistente a gonadotrofinas
síndrome del ovario resistente a las gonadotropinas
Scope note: Cese de la función ovárica que ocurre después de la MENARQUIA pero antes de los 40 años de edad, con o sin depleción de los folículos ováricos. Se caracteriza por la presencia de OLIGOMENORREA o AMENORREA, GONADOTROPINAS elevadas y concentraciones bajas de ESTRADIOL. Es un estado de HIPOGONADISMO hipergonadotrópico. Entre las causas se encuentran defectos genéticos, procesos autoinmunitarios, la quimioterapia, la radiación e infecciones. La causa genética conocida más frecuente es la expansión de una repetición CGG a entre 55 y 199 copias en la región 5' no traducida del gen FMR1 ligado al cromosoma X.
Descriptor Portuguese: Insuficiência Ovariana Primária
Descriptor French: Insuffisance ovarienne primitive
Entry term(s): FMR1 Related Primary Ovarian Insufficiency
FMR1-Related Primary Ovarian Insufficiency
Fragile X Associated Primary Ovarian Insufficiency
Fragile X Premature Ovarian Failure
Fragile X-Associated Primary Ovarian Insufficiency
Gonadotropin Resistant Ovary Syndrome
Gonadotropin-Resistant Ovary Syndrome
Hypergonadotropic Ovarian Failure, X Linked
Hypergonadotropic Ovarian Failure, X-Linked
Ovarian Failure, Premature
Ovarian Insufficiency, Primary
Premature Ovarian Failure
Premature Ovarian Failure 1
Premature Ovarian Failure, X Linked
Premature Ovarian Failure, X-Linked
Primary Ovarian Insufficiency, Fragile X Associated
Primary Ovarian Insufficiency, Fragile X-Associated
Resistant Ovary Syndrome
X Linked Hypergonadotropic Ovarian Failure
X-Linked Hypergonadotropic Ovarian Failure
Tree number(s): C12.050.351.500.056.630.750
C12.100.250.056.630.750
C19.391.630.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016649
Scope note: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Menopause, Premature (1975-1991)
Ovarian Diseases (1966-1991)
Public MeSH Note: 2011; see Ovarian Failure, Premature 1992-2010
History Note: 2011(1992)
Related: Menopause, Premature MeSH
DeCS ID: 30289
Unique ID: D016649
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2019/07/05
Primary Ovarian Insufficiency - Preferred
Concept UI M0025370
Scope note Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
Preferred term Primary Ovarian Insufficiency
Entry term(s) Ovarian Failure, Premature
Ovarian Insufficiency, Primary
Premature Ovarian Failure
Gonadotropin-Resistant Ovary Syndrome - Narrower
Concept UI M0025371
Scope note A form of ovarian failure, caused by resistance to GONADOTROPINS stimulation. It may be caused by defects in the receptors for FOLLICLE STIMULATING HORMONE or LUTEINIZING HORMONE. It may be due to factors interfering with the actions of gonadotropins, such as antibodies blocking the ligand-receptor interaction.
Preferred term Gonadotropin-Resistant Ovary Syndrome
Entry term(s) Gonadotropin Resistant Ovary Syndrome
Resistant Ovary Syndrome
Fragile X-Associated Primary Ovarian Insufficiency - Narrower
Concept UI M0574752
Preferred term Fragile X-Associated Primary Ovarian Insufficiency
Entry term(s) FMR1 Related Primary Ovarian Insufficiency
FMR1-Related Primary Ovarian Insufficiency
Fragile X Associated Primary Ovarian Insufficiency
Fragile X Premature Ovarian Failure
Premature Ovarian Failure 1
Primary Ovarian Insufficiency, Fragile X Associated
Primary Ovarian Insufficiency, Fragile X-Associated
Hypergonadotropic Ovarian Failure, X-Linked - Narrower
Concept UI M000648342
Preferred term Hypergonadotropic Ovarian Failure, X-Linked
Entry term(s) Hypergonadotropic Ovarian Failure, X Linked
Premature Ovarian Failure, X Linked
Premature Ovarian Failure, X-Linked
X Linked Hypergonadotropic Ovarian Failure
X-Linked Hypergonadotropic Ovarian Failure



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