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Descriptor English: GTP Pyrophosphokinase
Descriptor Spanish: GTP Pirofosfoquinasa
Descriptor GTP pirofosfocinasa
Entry term(s) ATP-guanosina fosfato pirofosfotransferasa
factor estricto
Scope note: Enzima que cataliza reversiblemente la transferencia del grupo pirofosfato del ATP al grupo 3'-OH del GDP o GTP, con formación de guanosina 3'-difosfato 5'-difosfato o guanosina 3'-difosfato 5'-trifosfato y AMP. La enzima, también llamada factor estricto, está localizada en el gen reIA en cepas estrictas de bacterias. La síntesis anterior es inducida por el ARNm y por el ARNt no cargado unido al sitio de enlace ribosómico del aminoacil-t-ARN por una asociación específica del codón. EC 2.7.6.5.
Descriptor Portuguese: GTP Pirofosfoquinase
Descriptor French: GTP pyrophosphokinase
Entry term(s): ATP Guanosine Phosphate Pyrophosphotransferase
ATP-Guanosine Phosphate Pyrophosphotransferase
Factor, Stringent
Pyrophosphokinase, GTP
Pyrophosphotransferase, ATP-Guanosine Phosphate
Stringent Factor
Tree number(s): D08.811.913.696.175.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001277
Scope note: An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.6.5
CAS Type 1 Name: ATP:GTP 3'-pyrophosphotransferase
Previous Indexing: Adenosine Triphosphate (1966-1979)
Bacterial Proteins (1966-1979)
Guanine Nucleotides (1966-1979)
Phosphotransferases (1966-1973)
Phosphotransferases, ATP (1974-1979)
Pyrophosphates (1966-1979)
Ribosomal Proteins (1975-1979)
Public MeSH Note: 92; was ATP-GUANOSINE PHOSPHATE PYROPHOSPHOTRANSFERASE 1980-91 (see under PHOSPHOTRANSFERASES, ATP 1980-90)
Online Note: use GTP PYROPHOSPHOKINASE to search ATP-GUANOSINE PHOSPHATE PYROPHOSPHOTRANSFERASE 1980-91
History Note: 92; was ATP-GUANOSINE PHOSPHATE PYROPHOSPHOTRANSFERASE 1980-91 (see under PHOSPHOTRANSFERASES, ATP 1980-90)
DeCS ID: 30302
Unique ID: D001277
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1979/05/23
Revision Date: 2003/07/09
GTP Pyrophosphokinase - Preferred
Concept UI M0001920
Scope note An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH group of GDP or GTP with the formation of guanosine 3'-diphosphate 5'-diphosphate or guanosine 3'-diphosphate 5'-triphosphate and AMP. The enzyme, also called stringent factor, is located in the relA gene in stringent strains of bacteria. The above synthesis is induced by mRNA and uncharged tRNA which is bound to the aminoacyl-t-RNA binding site of the ribosome by a codon-specific association. EC 2.7.6.5.
Preferred term GTP Pyrophosphokinase
Entry term(s) ATP Guanosine Phosphate Pyrophosphotransferase
ATP-Guanosine Phosphate Pyrophosphotransferase
Factor, Stringent
Pyrophosphokinase, GTP
Pyrophosphotransferase, ATP-Guanosine Phosphate
Stringent Factor



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