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Descriptor English: Epilepsy, Tonic-Clonic
Descriptor Spanish: Epilepsia Tónico-Clónica
Descriptor epilepsia tonicoclónica
Entry term(s) epilepsia de gran mal
epilepsia mayor
trastorno convulsivo de gran mal
trastorno convulsivo motor mayor
trastorno de crisis motora mayor
trastorno de crisis tonicoclónica
trastorno de crisis tonicoclónicas
trastorno de crisis tónico-clónica
Scope note: Trastorno epiléptico generalizado que se caracteriza por convulsiones motoras mayores recurrentes. La fase inicial tónica es breve y se caracteriza por flexión del tronco seguida de extensión difusa del tronco y de las extremidades. La fase clónica se caracteriza por contracciones flexoras rítmicas del tronco y extremidades, dilatación pupilar, elevación de la presión sanguínea y del pulso, incontinencia urinaria y mordedura de la lengua. Sigue un estado de profunda depresión de la conciencia (estado post-ictal) que mejora gradualmente en minutos a horas. La enfermedad puede ser criptogénica, familiar o sintomática (ocasionada por un proceso patológico identificado). (Adams et al., Principles of Neurology, 6th ed, p329)
Descriptor Portuguese: Epilepsia Tônico-Clônica
Descriptor French: Grand mal épileptique
Entry term(s): Convulsion Disorder, Tonic-Clonic
Convulsion Disorders, Tonic-Clonic
Convulsion Syndrome, Tonic-Clonic
Convulsion Syndromes, Tonic-Clonic
Convulsion, Grand Mal
Convulsion, Tonic Clonic
Convulsions, Grand Mal
Convulsions, Tonic Clonic
Cryptogenic Tonic Clonic Epilepsy
Cryptogenic Tonic-Clonic Epilepsies
Cryptogenic Tonic-Clonic Epilepsy
Disorder, Tonic-Clonic Convulsion
Disorder, Tonic-Clonic Seizure
Disorders, Tonic-Clonic Convulsion
Disorders, Tonic-Clonic Seizure
Epilepsies, Cryptogenic Tonic-Clonic
Epilepsies, Familial Tonic-Clonic
Epilepsies, Symptomatic Tonic-Clonic
Epilepsies, Tonic-Clonic
Epilepsy, Cryptogenic Tonic-Clonic
Epilepsy, Familial Tonic-Clonic
Epilepsy, Grand Mal
Epilepsy, Major
Epilepsy, Symptomatic Tonic-Clonic
Epilepsy, Tonic Clonic
Epilepsy, Tonic-Clonic, Cryptogenic
Epilepsy, Tonic-Clonic, Familial
Epilepsy, Tonic-Clonic, Symptomatic
Familial Tonic Clonic Epilepsy
Familial Tonic-Clonic Epilepsies
Familial Tonic-Clonic Epilepsy
Grand Mal Convulsion
Grand Mal Convulsions
Grand Mal Epilepsy
Grand Mal Seizure Disorder
Major Epilepsies
Major Epilepsy
Major Motor Seizure Disorder
Seizure Disorder, Grand Mal
Seizure Disorder, Major Motor
Seizure Disorder, Tonic Clonic
Seizure Disorder, Tonic-Clonic
Seizure Disorders, Tonic-Clonic
Seizure Syndrome, Tonic-Clonic
Seizure Syndromes, Tonic-Clonic
Symptomatic Tonic Clonic Epilepsy
Symptomatic Tonic-Clonic Epilepsies
Symptomatic Tonic-Clonic Epilepsy
Syndrome, Tonic-Clonic Convulsion
Syndrome, Tonic-Clonic Seizure
Syndromes, Tonic-Clonic Convulsion
Syndromes, Tonic-Clonic Seizure
Tonic Clonic Convulsion
Tonic Clonic Convulsion Disorder
Tonic Clonic Convulsion Syndrome
Tonic Clonic Convulsions
Tonic Clonic Seizure Disorder
Tonic Clonic Seizure Syndrome
Tonic-Clonic Convulsion Disorder
Tonic-Clonic Convulsion Disorders
Tonic-Clonic Convulsion Syndrome
Tonic-Clonic Convulsion Syndromes
Tonic-Clonic Epilepsies
Tonic-Clonic Epilepsies, Cryptogenic
Tonic-Clonic Epilepsies, Familial
Tonic-Clonic Epilepsies, Symptomatic
Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsy, Cryptogenic
Tonic-Clonic Epilepsy, Familial
Tonic-Clonic Epilepsy, Symptomatic
Tonic-Clonic Seizure Disorder
Tonic-Clonic Seizure Disorders
Tonic-Clonic Seizure Syndrome
Tonic-Clonic Seizure Syndromes
Tree number(s): C10.228.140.490.375.290
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004830
Scope note: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Annotation: do not confuse with EPILEPSY, TONIC see EPILEPSY, GENERALIZED
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Public MeSH Note: 1992; see EPILEPSY, GRAND MAL 1963-1991
History Note: 1992(1963)
DeCS ID: 30330
Unique ID: D004830
NLM Classification: WL 385
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/07/30
Epilepsy, Tonic-Clonic - Preferred
Concept UI M0007573
Scope note A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Preferred term Epilepsy, Tonic-Clonic
Entry term(s) Convulsion Disorder, Tonic-Clonic
Convulsion Disorders, Tonic-Clonic
Convulsion Syndrome, Tonic-Clonic
Convulsion Syndromes, Tonic-Clonic
Convulsion, Grand Mal
Convulsion, Tonic Clonic
Convulsions, Grand Mal
Convulsions, Tonic Clonic
Disorder, Tonic-Clonic Convulsion
Disorder, Tonic-Clonic Seizure
Disorders, Tonic-Clonic Convulsion
Disorders, Tonic-Clonic Seizure
Epilepsies, Tonic-Clonic
Epilepsy, Grand Mal
Epilepsy, Major
Epilepsy, Tonic Clonic
Grand Mal Convulsion
Grand Mal Convulsions
Grand Mal Epilepsy
Grand Mal Seizure Disorder
Major Epilepsies
Major Epilepsy
Major Motor Seizure Disorder
Seizure Disorder, Grand Mal
Seizure Disorder, Major Motor
Seizure Disorder, Tonic Clonic
Seizure Disorder, Tonic-Clonic
Seizure Disorders, Tonic-Clonic
Seizure Syndrome, Tonic-Clonic
Seizure Syndromes, Tonic-Clonic
Syndrome, Tonic-Clonic Convulsion
Syndrome, Tonic-Clonic Seizure
Syndromes, Tonic-Clonic Convulsion
Syndromes, Tonic-Clonic Seizure
Tonic Clonic Convulsion
Tonic Clonic Convulsion Disorder
Tonic Clonic Convulsion Syndrome
Tonic Clonic Convulsions
Tonic Clonic Seizure Disorder
Tonic Clonic Seizure Syndrome
Tonic-Clonic Convulsion Disorder
Tonic-Clonic Convulsion Disorders
Tonic-Clonic Convulsion Syndrome
Tonic-Clonic Convulsion Syndromes
Tonic-Clonic Epilepsies
Tonic-Clonic Epilepsy
Tonic-Clonic Seizure Disorder
Tonic-Clonic Seizure Disorders
Tonic-Clonic Seizure Syndrome
Tonic-Clonic Seizure Syndromes
Epilepsy, Tonic-Clonic, Symptomatic - Narrower
Concept UI M0335131
Preferred term Epilepsy, Tonic-Clonic, Symptomatic
Entry term(s) Epilepsies, Symptomatic Tonic-Clonic
Epilepsy, Symptomatic Tonic-Clonic
Symptomatic Tonic Clonic Epilepsy
Symptomatic Tonic-Clonic Epilepsies
Symptomatic Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsies, Symptomatic
Tonic-Clonic Epilepsy, Symptomatic
Cryptogenic Tonic-Clonic Epilepsy - Narrower
Concept UI M0335129
Preferred term Cryptogenic Tonic-Clonic Epilepsy
Entry term(s) Cryptogenic Tonic Clonic Epilepsy
Cryptogenic Tonic-Clonic Epilepsies
Epilepsies, Cryptogenic Tonic-Clonic
Epilepsy, Cryptogenic Tonic-Clonic
Epilepsy, Tonic-Clonic, Cryptogenic
Tonic-Clonic Epilepsies, Cryptogenic
Tonic-Clonic Epilepsy, Cryptogenic
Epilepsy, Tonic-Clonic, Familial - Narrower
Concept UI M0335130
Preferred term Epilepsy, Tonic-Clonic, Familial
Entry term(s) Epilepsies, Familial Tonic-Clonic
Epilepsy, Familial Tonic-Clonic
Familial Tonic Clonic Epilepsy
Familial Tonic-Clonic Epilepsies
Familial Tonic-Clonic Epilepsy
Tonic-Clonic Epilepsies, Familial
Tonic-Clonic Epilepsy, Familial



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