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Descriptor English: Immunoglobulin J-Chains
Descriptor Spanish: Cadenas J de Inmunoglobulina
Descriptor cadenas J de inmunoglobulinas
Entry term(s) cadenas J de las Ig
cadenas J de las inmunoglobulinas
Scope note: Péptido "de unión" de 15 kDa que forma una de las uniones entre monómeros de INMUNOGLOBULINA A o INMUNOGLOBULINA M en la formación de inmunoglobulinas poliméricas. Hay una cadena J por cada dímero de IgA o pentámero de IgM. También participa en la unión de las inmunoglobulinas poliméricas a los RECEPTORES DE INMUNOGLOBULINAS POLIMÉRICAS, necesaria para su transcitosis a la luz. Se distingue de la REGIÓN DE UNIÓN DE LAS INMUNOGLOBULINAS, que es parte de la REGIÓN VARIABLE DE LAS INMUNOGLOBULINAS de las cadenas ligeras y pesadas de la inmunoglobulina.
Descriptor Portuguese: Cadeias J de Imunoglobulina
Descriptor French: Chaines J des immunoglobulines
Entry term(s): Chains, Ig J
Ig J Chains
Ig J Peptide
Ig J-Peptide
Immunoglobulin J Chains
Immunoglobulin J Peptide
Immunoglobulin J Polypeptide
Immunoglobulin J-Peptide
J Chains, Ig
J Chains, Immunoglobulin
J Polypeptide, Immunoglobulin
J-Chains, Immunoglobulin
J-Peptide, Ig
J-Peptide, Immunoglobulin
Polypeptide, Immunoglobulin J
Tree number(s): D12.776.124.486.485.705.625
D12.776.124.790.651.705.625
D12.776.377.715.548.705.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007144
Scope note: A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Public MeSH Note: 2006; see IMMUNOGLOBULINS, J-CHAIN 1992-2005, see IMMUNOGLOBULINS, J CHAIN 1974-1991
History Note: 2006 (1974)
Entry Version: IG J CHAINS
Related: Immunoglobulin A MeSH
Immunoglobulin M MeSH
DeCS ID: 30363
Unique ID: D007144
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/07/02
Immunoglobulin J-Chains - Preferred
Concept UI M0011135
Scope note A 15 kDa "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
Preferred term Immunoglobulin J-Chains
Entry term(s) Chains, Ig J
Ig J Chains
Ig J Peptide
Ig J-Peptide
Immunoglobulin J Chains
Immunoglobulin J Peptide
Immunoglobulin J Polypeptide
Immunoglobulin J-Peptide
J Chains, Ig
J Chains, Immunoglobulin
J Polypeptide, Immunoglobulin
J-Chains, Immunoglobulin
J-Peptide, Ig
J-Peptide, Immunoglobulin
Polypeptide, Immunoglobulin J



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