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Descriptor English: Cocaine
Descriptor Spanish: Cocaína
Descriptor cocaína
Entry term(s) clorhidrato de cocaína
Scope note: Éster alcaloide extraido de las hojas de plantas como la coca. Es un anestésico y vasoconstrictor local y clínicamente se utiliza con esta finalidad, especialmente en oftalmología y procesos del oído, nariz y garganta. También tiene potentes efectos sobre el sistema nervioso central, similares a los de las anfetaminas y es una droga de adicción. Como las anfetaminas, actua mediante múltiples mecanismos sobre las neuronas catecolaminérgicas cerebrales; se piensa que el mecanismo de sus efectos de reforzamiento implica la inhibición de la recaptación de serotonina.
Descriptor Portuguese: Cocaína
Descriptor French: Cocaïne
Entry term(s): Cocaine HCl
Cocaine Hydrochloride
HCl, Cocaine
Hydrochloride, Cocaine
Tree number(s): D02.145.074.722.388
D03.132.889.354
D03.605.084.500.722.388
D03.605.869.388
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003042
Scope note: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Annotation: cocaine derivatives = COCAINE /analogs; CRACK COCAINE, COCAINE SMOKING and COCAINE-RELATED DISORDERS are available
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anesthetics, Local
Vasoconstrictor Agents
Dopamine Uptake Inhibitors
Registry Number: I5Y540LHVR
CAS Type 1 Name: 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-
Public MeSH Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74
History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
Related: Cocainum Hydrochloricum DeCS
DeCS ID: 3070
Unique ID: D003042
NLM Classification: QV 113
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Cocaine - Preferred
Concept UI M0004670
Scope note An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Preferred term Cocaine
Cocaine Hydrochloride - Narrower
Concept UI M0330572
Preferred term Cocaine Hydrochloride
Entry term(s) Cocaine HCl
HCl, Cocaine
Hydrochloride, Cocaine



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