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Descriptor in English: Cocaine
Descriptor in Spanish: Cocaína
Descriptor in Portuguese: Cocaína
Descriptor in French: Cocaïne
Entry term(s): Cocaine HCl
Cocaine Hydrochloride
HCl, Cocaine
Hydrochloride, Cocaine
Tree number(s): D02.145.074.722.388
D03.132.889.354
D03.605.084.500.722.388
D03.605.869.388
Scope note: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Annotation: cocaine derivatives = COCAINE /analogs; CRACK COCAINE, COCAINE SMOKING and COCAINE-RELATED DISORDERS are available
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Online Note: use COCAINE/analogs & derivatives to search COCAINE DERIVATIVES 1975-77; use TROPANES 1969-74
History Note: COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
See also the descriptors: Cocainum Hydrochloricum DeCS
DeCS UI: 3070
Descriptor UI: D003042
Date Established: 1960/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Cocaine - Preferred
Concept UI M0004670
Scope note An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Preferred term Cocaine
Cocaine Hydrochloride - Narrower
Concept UI M0330572
Preferred term Cocaine Hydrochloride
Entry term(s) Cocaine HCl
HCl, Cocaine
Hydrochloride, Cocaine



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