DeCS

Descriptor English:

Complement Factor H

Descriptor Spanish:

Factor H de Complemento

Spanish from Spain

Descriptor	factor H del complemento
Entry term(s)	factor H
Scope note:	Importante regulador soluble de la vía alternativa de activación del complemento (VÍA ALTERNATIVA DE ACTIVACIÓN DEL COMPLEMENTO). Es una glicoproteína de 139 kDa que se expresa por el hígado y se segrega a la sangre. Se une al COMPLEMENTO C3B y hace que iC3b (complemento 3b inactivado) sea susceptible al desdoblamiento por el FACTOR I DEL COMPLEMENTO. El factor H del complemento inhibe también la asociación de C3b con el FACTOR B DEL COMPLEMENTO para formar la proenzima C3bB, y promueve la disociación de Bb del complejo C3bBb (CONVERTASA C3 DE LA VÍA ALTERNATIVA DEL COMPLEMENTO).

Descriptor Portuguese:

Fator H do Complemento

Descriptor French:

Facteur H du complément

Entry term(s):

Facteur H
Facteur H complémentaire

Tree number(s):

D12.776.124.486.274.920.325.200
D12.776.124.790.223.200
D12.776.377.715.182.200

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D017242

Scope note:

An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

Allowable Qualifiers:

AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine

Pharm Action:

Complement Inactivating Agents

Registry Number:

80295-65-4

CAS Type 1 Name:

Complement factor H

DeCS ID:

30775

Unique ID:

D017242

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents