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Descriptor English: Sex Hormone-Binding Globulin
Descriptor Spanish: Globulina de Unión a Hormona Sexual
Descriptor Portuguese: Globulina de Ligação a Hormônio Sexual
Descriptor French: Globuline de liaison aux hormones sexuelles
Entry term(s): Binding Globulin, Testosterone-Estradiol
Globulin, Sex Hormone-Binding
Globulin, Testosterone-Estradiol Binding
Hormone-Binding Globulin, Sex
Sex Hormone Binding Globulin
Sex Steroid Binding Protein
Sex Steroid-Binding Protein
Steroid-Binding Protein, Sex
Testosterone Estradiol Binding Globulin
Testosterone-Estradiol Binding Globulin
Tree number(s): D12.776.124.790.223.800
D12.776.157.762
D12.776.377.715.182.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012738
Scope note: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Annotation: does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN; DF: SHBG
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Beta Globulins (1974-1976)
Carrier Proteins (1971-1991)
Glycoproteins (1974-1975)
Protein Binding (1974-1975)
Sex Hormones (1974-1976)
Public MeSH Note: 77; SEX-STEROID-BINDING PROTEIN was indexed under CARRIER PROTEINS 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92
Online Note: use SEX HORMONE-BINDING GLOBULIN (NM) to search SEX-STEROID-BINDING PROTEIN 1981-91; use SEX HORMONE-BINDING GLOBULIN to search ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN 1977-92
History Note: 77; SEX STEROID-BINDING PROTEIN was SEX-STEROID-BINDING PROTEIN (NM) 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92
Entry Version: SHBG
Related: Androgen-Binding Protein MeSH
DeCS ID: 22292
Unique ID: D012738
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1977/01/01
Date of Entry: 1976/04/16
Revision Date: 2004/08/02
Sex Hormone-Binding Globulin - Preferred
Concept UI M0019743
Scope note A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.
Preferred term Sex Hormone-Binding Globulin
Entry term(s) Binding Globulin, Testosterone-Estradiol
Globulin, Sex Hormone-Binding
Globulin, Testosterone-Estradiol Binding
Hormone-Binding Globulin, Sex
Sex Hormone Binding Globulin
Sex Steroid Binding Protein
Sex Steroid-Binding Protein
Steroid-Binding Protein, Sex
Testosterone Estradiol Binding Globulin
Testosterone-Estradiol Binding Globulin



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