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Descriptor English: Alternative Splicing
Descriptor Spanish: Empalme Alternativo
Descriptor empalme alternativo
Entry term(s) ayuste alternativo
ayuste alternativo de ARN
Scope note: Proceso mediante el cual se generan múltiples transcritos de ARN a partir de un solo gen. El ayuste alternativo involucra el ayuste junto con otros posibles conjuntos de EXONES durante el procesamiento de algunos transcritos, pero no todos, del gen. Así, un determinado exón puede estar conectado a alguno de diversos exones alternativos para formar un ARN maduro. Las formas alternativas de ARN MENSAJERO maduro producen ISOFORMAS DE PROTEÍNAS, en las que una parte de las isoformas es común mientras que las demás partes son diferentes.
Descriptor Portuguese: Processamento Alternativo
Descriptor French: Épissage alternatif
Entry term(s): Alternate Splicing
Alternate Splicings
Alternative RNA Splicing
Alternative RNA Splicings
Alternative Splicings
Nested Transcript
Nested Transcripts
RNA Splicing, Alternative
RNA Splicings, Alternative
Splicing, Alternate
Splicing, Alternative
Splicing, Alternative RNA
Splicings, Alternate
Splicings, Alternative
Splicings, Alternative RNA
Transcript, Nested
Transcripts, Nested
Tree number(s): G02.111.760.700.100
G03.839.700.100
G05.308.700.700.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017398
Scope note: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Annotation: for NESTED TRANSCRIPTS also index the RNA; do not confuse with NESTED GENES; for nested primers use NESTED PCR; (POLYMERASE CHAIN REACTION)
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: RNA Splicing (1982-1992)
Public MeSH Note: 93
History Note: 93
Related: Nested Genes MeSH
Protein Isoforms MeSH
RNA Splice Sites MeSH
DeCS ID: 30858
Unique ID: D017398
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/13
Revision Date: 2016/05/02
Alternative Splicing - Preferred
Concept UI M0026412
Scope note A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Preferred term Alternative Splicing
Entry term(s) Alternate Splicing
Alternate Splicings
Alternative RNA Splicing
Alternative RNA Splicings
Alternative Splicings
RNA Splicing, Alternative
RNA Splicings, Alternative
Splicing, Alternate
Splicing, Alternative
Splicing, Alternative RNA
Splicings, Alternate
Splicings, Alternative
Splicings, Alternative RNA
Nested Transcripts - Related but not broader or narrower
Concept UI M0411969
Scope note Alternatively spliced RNA transcripts that are derived from a set of exons that are located in the middle of the primary transcript (RNA PRECURSORS), between unused exons.
Preferred term Nested Transcripts
Entry term(s) Nested Transcript
Transcript, Nested
Transcripts, Nested



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