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Descriptor English: Fenclonine
Descriptor Spanish: Fenclonina
Descriptor fenclonina
Entry term(s) p-clorofenilalanina
para-clorofenilalanina
Scope note: Inhibidor selectivo e irreversible de la triptófano hidrolasa, enzima limitante de la velocidad en la biosíntesis de serotononina (5-HIDROXITRIPTAMINA). La fenclonina actúa farmacológicamente para disminuir las concentraciones endógenas de serotonina.
Descriptor Portuguese: Fenclonina
Descriptor French: Fenclonine
Entry term(s): CP-10,188
DL-3-(4-Chlorophenyl)alanine
Fenclonin
Fenclonine (L)-Isomer
Fenclonine Hydrobromide
Fenclonine Hydrochloride
Fenclonine, (D)-Isomer
Hydrobromide, Fenclonine
Hydrochloride, Fenclonine
p-Chlorophenylalanine
para Chlorophenylalanine
para-Chlorophenylalanine
Tree number(s): D12.125.072.050.685.440
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010134
Scope note: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Enzyme Inhibitors
Serotonin Antagonists
Registry Number: R5J7E3L9SP
CAS Type 1 Name: DL-Phenylalanine, 4-chloro-
Previous Indexing: Phenylalanine (1966-1970)
Public MeSH Note: 93; see P-CHLOROPHENYLALANINE 1973-92; for FENCLONINE see P-CHLOROPHENYLALANINE 1978-92
History Note: 93(71)
DeCS ID: 30927
Unique ID: D010134
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Fenclonine - Preferred
Concept UI M0015725
Scope note A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Preferred term Fenclonine
Entry term(s) DL-3-(4-Chlorophenyl)alanine
Fenclonin
p-Chlorophenylalanine
para Chlorophenylalanine
para-Chlorophenylalanine
Fenclonine, (D)-Isomer - Narrower
Concept UI M0329929
Preferred term Fenclonine, (D)-Isomer
Fenclonine Hydrobromide - Narrower
Concept UI M0329934
Preferred term Fenclonine Hydrobromide
Entry term(s) Hydrobromide, Fenclonine
Fenclonine Hydrochloride - Narrower
Concept UI M0329933
Preferred term Fenclonine Hydrochloride
Entry term(s) Hydrochloride, Fenclonine
CP-10,188 - Narrower
Concept UI M0363633
Preferred term CP-10,188
Fenclonine (L)-Isomer - Narrower
Concept UI M0329930
Preferred term Fenclonine (L)-Isomer



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