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Descriptor English: Immunoglobulin Class Switching
Descriptor Spanish: Cambio de Clase de Inmunoglobulina
Descriptor cambio de clase de las inmunoglobulinas
Entry term(s) cambio de clase de las Ig
cambio de isotipos
conmutación de inmunoglobulinas
Scope note: Reordenamiento génico del linfocito B que conduce a una sustitución en el tipo de región constante de la cadena pesada que se expresa. Esto permite que la respuesta efectora cambie mientras que la especificidad de unión del antígeno (región variable) se mantiene igual. La mayoría de los cambios de clase ocurren por recombinación del ADN, pero también puede tener lugar en el procesamiento del ARN.
Descriptor Portuguese: Switching de Imunoglobulina
Descriptor French: Commutation de classe des immunoglobulines
Entry term(s): Class Switching
Class Switching, Ig
Class Switching, Immunoglobulin
Class Switchings
Class Switchings, Ig
Class Switchings, Immunoglobulin
Ig Class Switching
Ig Class Switchings
Immunoglobulin Class Switchings
Isotype Switching
Isotype Switchings
Switching, Class
Switching, Ig Class
Switching, Immunoglobulin Class
Switching, Isotype
Switchings, Class
Switchings, Ig Class
Switchings, Immunoglobulin Class
Switchings, Isotype
Tree number(s): G05.344.401.501.450
G12.500.274.501.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017578
Scope note: Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Immunoglobulin Isotypes/biosynthesis (1988-1993)
Immunoglobulins, Heavy-Chain/genetics (1980-1993)
Public MeSH Note: 94
History Note: 94
Entry Version: IG CLASS SWITCHING
DeCS ID: 31391
Unique ID: D017578
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/17
Revision Date: 2019/07/05
Immunoglobulin Class Switching - Preferred
Concept UI M0026640
Scope note Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Preferred term Immunoglobulin Class Switching
Entry term(s) Class Switching
Class Switching, Ig
Class Switching, Immunoglobulin
Class Switchings
Class Switchings, Ig
Class Switchings, Immunoglobulin
Ig Class Switching
Ig Class Switchings
Immunoglobulin Class Switchings
Isotype Switching
Isotype Switchings
Switching, Class
Switching, Ig Class
Switching, Immunoglobulin Class
Switching, Isotype
Switchings, Class
Switchings, Ig Class
Switchings, Immunoglobulin Class
Switchings, Isotype



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