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Descriptor English: Electroporation
Descriptor Spanish: Electroporación
Descriptor electroporación
Entry term(s) electroporación irreversible
electroporación reversible
permeabilización celular por campo eléctrico
Scope note: Técnica en la que impulsos eléctricos, en kilovoltios por centímetro y de una duración de entre microsegundos y milisegundos, causan una pérdida de la semipermeabilidad de las MEMBRANAS CELULARES provocando fuga de iones, escape de metabolitos y una mayor captación de fármacos, sondas moleculares y ADN por parte de las células. Dependiendo de la dosis, la formación de aberturas en las membranas celulares provocadas por los impulsos eléctricos puede o no ser reversible.
Descriptor Portuguese: Eletroporação
Descriptor French: Électroporation
Entry term(s): Electric Field-Mediated Cell Permeabilization
Electropermeabilisation
Electroporation, Irreversible
Electroporation, Reversible
Irreversible Electroporation
Reversible Electroporation
Tree number(s): E05.200.500.454
E05.242.448
E05.301.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018274
Scope note: A technique in which electric pulses, in kilovolts per centimeter and of microsecond-to-millisecond duration, cause a loss of the semipermeability of CELL MEMBRANES, thus leading to ion leakage, escape of metabolites, and increased uptake by cells of drugs, molecular probes, and DNA. Depending on the dosage, the formation of openings in the cell membranes caused by the electric pulses may or may not be reversible.
Allowable Qualifiers: CL classification
EC economics
ES ethics
HI history
IS instrumentation
MT methods
SN statistics & numerical data
ST standards
TD trends
VE veterinary
Public MeSH Note: 94
History Note: 94
DeCS ID: 31491
Unique ID: D018274
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2022/04/08
Electroporation - Preferred
Concept UI M0027505
Scope note A technique in which electric pulses, in kilovolts per centimeter and of microsecond-to-millisecond duration, cause a loss of the semipermeability of CELL MEMBRANES, thus leading to ion leakage, escape of metabolites, and increased uptake by cells of drugs, molecular probes, and DNA. Depending on the dosage, the formation of openings in the cell membranes caused by the electric pulses may or may not be reversible.
Preferred term Electroporation
Entry term(s) Electric Field-Mediated Cell Permeabilization
Electropermeabilisation
Irreversible Electroporation - Narrower
Concept UI M000752590
Scope note Cell permeabilization induced by higher intensity voltages that cause irreparable cell membrane openings which triggers APOPTOSIS.
Preferred term Irreversible Electroporation
Entry term(s) Electroporation, Irreversible
Reversible Electroporation - Narrower
Concept UI M000752591
Scope note Application of electric pulses to cells in doses that cause only temporary permeabilization of CELL MEMBRANES.
Preferred term Reversible Electroporation
Entry term(s) Electroporation, Reversible



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