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Descriptor English: Tyrocidine
Descriptor Spanish: Tirocidina
Descriptor tirocidina
Scope note: Mezcla antibiótica producida por Bacillus brevis que puede separarse en tres componentes, las tirocidinas A, B y C. Es el constituyente principal (40-60 por ciento) de la tirotricina, mientras que la gramicidina constituye el 10-20 por ciento restante del material activo. Es un antimicrobiano tópico que resulta muy tóxico por vía parenteral.
Descriptor Portuguese: Tirocidina
Descriptor French: Tyrocidine
Entry term(s): Brevicidin
Rapicidin
Tyrocidines
Tree number(s): D04.345.566.850.920
D12.644.641.850.920
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014440
Scope note: An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Infective Agents, Local
Anti-Bacterial Agents
Previous Indexing: Peptides, Cyclic (1974)
Tyrothricin (1966-1974)
Public MeSH Note: 94; was TYROCIDINES 1975-93 (see under TYROTHRICIN 1975-90)
Online Note: use TYROCIDINE to search TYROCIDINES 1975-93
History Note: 94; was TYROCIDINES 1975-93 (see under TYROTHRICIN 1975-90)
DeCS ID: 31784
Unique ID: D014440
NLM Classification: QV 220
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2015/06/23
Tyrocidine - Preferred
Concept UI M0022198
Scope note An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.
Preferred term Tyrocidine
Entry term(s) Tyrocidines
Rapicidin - Narrower
Concept UI M0022197
Preferred term Rapicidin
Brevicidin - Narrower
Concept UI M0022196
Preferred term Brevicidin



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