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Descriptor English: Procollagen-Proline Dioxygenase
Descriptor Spanish: Procolágeno-Prolina Dioxigenasa
Descriptor procolágeno-prolina dioxigenasa
Entry term(s) protocolágeno prolil hidroxilasa
Scope note: Oxigenasa de función mixta que cataliza la hidroxilación de un péptido que contiene prolil-glicilo, generalmente del PROTOCOLÁGENO, a un péptido que contiene hidroxiprolilglicilo. La enzima utiliza OXÍGENO molecular con una descarboxilación oxidativa concomitante del 2-oxoglutarato a SUCCINATO. La enzima se presenta como un tetrámero con dos subunidades beta y dos subunidades alfa. La subunidad beta de la procolágeno-prolina dioxigenasa es idéntica a la enzima PROTEÍNA-DISULFURO ISOMERASA.
Descriptor Portuguese: Pró-Colágeno-Prolina Dioxigenase
Descriptor French: Procollagen-Proline Dioxygenase
Entry term(s): 4-Hydroxylase, Procollagen Prolyl
Dioxygenase, Procollagen-Proline
Hydroxylase, Protocollagen Prolyl
Procollagen Proline Dioxygenase
Procollagen Prolyl 4 Hydroxylase
Procollagen Prolyl 4-Hydroxylase
Prolyl 4-Hydroxylase, Procollagen
Prolyl Hydroxylase, Protocollagen
Protocollagen Prolyl Hydroxylase
Tree number(s): D08.811.682.690.416.617.750
D08.811.682.690.708.694.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011393
Scope note: A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.2
CAS Type 1 Name: Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
Previous Indexing: Hydroxylases (1966-1971)
Public MeSH Note: 94; was PROLINE HYDROXYLASE 1974-93; PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93
Online Note: use PROCOLLAGEN-PROLINE DIOXYGENASE to search PROLINE HYDROXYLASE 1972-93 (as Prov 1972-73) & PROLINE,2-OXOGLUTARATE DIOXYGENASE 1977-93
History Note: 94; was PROLINE HYDROXYLASE 1972-93 (Prov 1972-73); PROLINE,2-OXOGLUTARATE 4-DIOXYGENASE was PROLINE,2-OXOGLUTARATE DIOXYGENASE see PROLINE HYDROXYLASE 1977-93
Related: Protein Disulfide-Isomerases MeSH
DeCS ID: 31898
Unique ID: D011393
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Procollagen-Proline Dioxygenase - Preferred
Concept UI M0017694
Scope note A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Preferred term Procollagen-Proline Dioxygenase
Entry term(s) 4-Hydroxylase, Procollagen Prolyl
Dioxygenase, Procollagen-Proline
Hydroxylase, Protocollagen Prolyl
Procollagen Proline Dioxygenase
Procollagen Prolyl 4 Hydroxylase
Procollagen Prolyl 4-Hydroxylase
Prolyl 4-Hydroxylase, Procollagen
Prolyl Hydroxylase, Protocollagen
Protocollagen Prolyl Hydroxylase



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