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Descriptor English: Polymorphism, Single-Stranded Conformational
Descriptor Spanish: Polimorfismo Conformacional Retorcido-Simple
Descriptor polimorfismo conformacional de cadena única
Entry term(s) SSCP
polimorfismo conformacional de cadena simple
polimorfismo conformacional de hebra simple
polimorfismo conformacional de hebra única
Scope note: Variación en una secuencia de ADN de una población que se detecta determinando alteraciones en la conformación de fragmentos de ADN desnaturalizados. Se deja que dichos fragmentos se renaturalicen en condiciones que impiden la formación de ADN de doble cadena y permiten que se forme una estructura secundaria en fragmentos de cadena simple. Luego estos fragmentos se corren en gel de poliacrilamida para detectar variaciones en la estructura secundaria que se manifiestan en una alteración de la migración en el gel.
Descriptor Portuguese: Polimorfismo Conformacional de Fita Simples
Descriptor French: Polymorphisme de conformation simple brin
Entry term(s): Conformational Polymorphism, Single-Stranded
Conformational Polymorphisms, Single-Stranded
Polymorphism, Single Stranded Conformational
Polymorphisms, Single-Stranded Conformational
SSCP
Single Stranded Conformational Polymorphism
Single-Stranded Conformational Polymorphism
Single-Stranded Conformational Polymorphisms
Tree number(s): G05.365.795.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018807
Scope note: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Annotation: POLYMORPHISM, SINGLE NUCLEOTIDE is also available
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Polymorphism (Genetics) (1990-1994)
Public MeSH Note: 1995
History Note: 1995
DeCS ID: 32072
Unique ID: D018807
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/05/31
Revision Date: 2008/07/08
Polymorphism, Single-Stranded Conformational - Preferred
Concept UI M0028160
Scope note Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Preferred term Polymorphism, Single-Stranded Conformational
Entry term(s) Conformational Polymorphism, Single-Stranded
Conformational Polymorphisms, Single-Stranded
Polymorphism, Single Stranded Conformational
Polymorphisms, Single-Stranded Conformational
SSCP
Single Stranded Conformational Polymorphism
Single-Stranded Conformational Polymorphism
Single-Stranded Conformational Polymorphisms



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