DeCS

Descriptor English:

Pharmacogenomic Variants

Descriptor Spanish:

Variantes Farmacogenómicas

Spanish from Spain

Descriptor	variantes farmacogenéticas
Entry term(s)	variantes farmacogenómicas variantes genéticas farmacocinéticas
Scope note:	Variaciones genéticas que se producen de manera natural asociadas a la respuesta a medicamentos (ej., dosis, magnitud y velocidad de los procesos metabólicos). Aunque estas variantes no se consideran marcadores para la PREDISPOSICIÓN GENÉTICA A LA ENFERMEDAD, afectan a la FARMACOCINÉTICA y farmacodinamia, y con frecuencia se producen en genes que codifican las enzimas y los transportadores responsables del metabolismo de los fármacos (p. ej., la ENZIMA CONVERTIDORA DE ANGIOTENSINA, el CITOCROMO P-450 y CYP2D6).

Descriptor Portuguese:

Variantes Farmacogenômicos

Descriptor French:

Variants pharmacogénomiques

Entry term(s):

Genetic Variant, Pharmacokinetic
Genetic Variants, Pharmacokinetic
Pharmacogenetic Variant
Pharmacogenetic Variants
Pharmacogenomic Variant
Pharmacokinetic Genetic Variant
Pharmacokinetic Genetic Variants
Variant, Pharmacogenetic
Variant, Pharmacogenomic
Variants, Pharmacogenetic
Variants, Pharmacogenomic

Tree number(s):

G05.365.795.446

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000071184

Scope note:

Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

Genetic Variation (1968-2016)
Pharmacogenetics (1968-2016)
Polymorphism, Genetic (1980-2016)

Public MeSH Note:

2017

History Note:

2017

Pharmacogenetics MeSH
Precision Medicine MeSH

DeCS ID:

56761

Unique ID:

D000071184

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2017/01/01

Date of Entry:

2016/07/08

Revision Date:

2016/01/20

PHENOMENA AND PROCESSES

Genetic Phenomena [G05]

Genetic Phenomena

Genetic Variation [G05.365]

Genetic Variation

Polymorphism, Genetic [G05.365.795]

Polymorphism, Genetic

Genomic Structural Variation [G05.365.795.297]

Genomic Structural Variation

Pharmacogenomic Variants [G05.365.795.446]

Pharmacogenomic Variants

Polymorphism, Restriction Fragment Length [G05.365.795.595]

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide [G05.365.795.598]

Polymorphism, Single Nucleotide

Polymorphism, Single-Stranded Conformational [G05.365.795.600]

Polymorphism, Single-Stranded Conformational

Pharmacogenomic Variants - Preferred

Concept UI	M000613458
Scope note	Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).
Preferred term	Pharmacogenomic Variants
Entry term(s)	Genetic Variant, Pharmacokinetic Genetic Variants, Pharmacokinetic Pharmacogenetic Variant Pharmacogenetic Variants Pharmacogenomic Variant Pharmacokinetic Genetic Variant Pharmacokinetic Genetic Variants Variant, Pharmacogenetic Variant, Pharmacogenomic Variants, Pharmacogenetic Variants, Pharmacogenomic

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