Search
Descriptor English: GABA Modulators
Descriptor Spanish: Moduladores del GABA
Descriptor Portuguese: Moduladores GABAérgicos
Descriptor French: Modulateurs GABA
Entry term(s): Acid Modulators, gamma-Aminobutyric
GABAergic Modulators
Modulators, GABA
Modulators, GABAergic
Modulators, gamma-Aminobutyric Acid
gamma Aminobutyric Acid Modulators
gamma-Aminobutyric Acid Modulators
Tree number(s): D27.505.519.625.240.500
D27.505.696.577.240.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018757
Scope note: Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Annotation: general or unspecified; prefer specifics
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Public MeSH Note: 95
History Note: 95
Related: Anesthetics, General MeSH
Anti-Anxiety Agents MeSH
Hypnotics and Sedatives MeSH
DeCS ID: 32238
Unique ID: D018757
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/06/03
Revision Date: 2005/06/30
GABA Modulators - Preferred
Concept UI M0028093
Scope note Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
Preferred term GABA Modulators
Entry term(s) Acid Modulators, gamma-Aminobutyric
GABAergic Modulators
Modulators, GABA
Modulators, GABAergic
Modulators, gamma-Aminobutyric Acid
gamma Aminobutyric Acid Modulators
gamma-Aminobutyric Acid Modulators



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey