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Descriptor English: Spheroids, Cellular
Descriptor Spanish: Esferoides Celulares
Descriptor esferoides celulares
Scope note: Agregados esféricos y heterogéneos de células proliferativas, quiescentes y necróticas en cultivo que conservan la arquitectura tridimensional y las funciones específicas del tejido. Representan un modelo in-vitro para estudios biológicos, tanto de células normales como de las malignas. Generalmente, la capacidad de formar esferoides es un rasgo característico de las CÉLULAS TUMORALES CULTIVADAS derivadas de TUMORES sólidos, aunque las células que proceden de tejidos normales también pueden formarlos. (Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
Descriptor Portuguese: Esferoides Celulares
Descriptor French: Sphéroïdes de cellules
Entry term(s): Cellular Spheroid
Cellular Spheroids
Multicellular Spheroid
Multicellular Spheroids
Spheroid, Cellular
Spheroid, Multicellular
Spheroids, Multicellular
Tree number(s): A11.251.800
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018874
Scope note: Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
Annotation: do not confuse with "spheroid bodies" referring to axons in neuropathol; if tumor spheroids coordinate with TUMOR CELLS, CULTURED
Allowable Qualifiers: CH chemistry
CL classification
CY cytology
DE drug effects
EN enzymology
IM immunology
ME metabolism
MI microbiology
PA pathology
PH physiology
PS parasitology
RE radiation effects
TR transplantation
UL ultrastructure
VI virology
Previous Indexing: Cells, Cultured (1972-1995)
Tissue Culture (1966-1971)
Tumor Cells, Cultured (1988-1995)
Public MeSH Note: 2004(1996); see SPHEROIDS 1996-2003
History Note: 2004(1996)
DeCS ID: 32606
Unique ID: D018874
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1994/12/27
Revision Date: 2003/07/09
Spheroids, Cellular - Preferred
Concept UI M0028227
Scope note Spherical, heterogeneous aggregates of proliferating, quiescent, and necrotic cells in culture that retain three-dimensional architecture and tissue-specific functions. The ability to form spheroids is a characteristic trait of CULTURED TUMOR CELLS derived from solid TUMORS. Cells from normal tissues can also form spheroids. They represent an in-vitro model for studies of the biology of both normal and malignant cells. (From Bjerkvig, Spheroid Culture in Cancer Research, 1992, p4)
Preferred term Spheroids, Cellular
Entry term(s) Cellular Spheroid
Cellular Spheroids
Multicellular Spheroid
Multicellular Spheroids
Spheroid, Cellular
Spheroid, Multicellular
Spheroids, Multicellular



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