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Descriptor English: Helix-Turn-Helix Motifs
Descriptor Spanish: Secuencias Hélice-Giro-Hélice
Descriptor motivos hélice-giro-hélice
Entry term(s) motivos HTH
Scope note: Se trata de los primeros motivos de unión a proteínas del ADN. Los motivos hélice-giro-hélice se identificaron originalmente en proteínas bacterianas pero, a partir de ese momento, se han encontrado en cientos de PROTEÍNAS DE UNIÓN AL ADN, tanto de eucariotas como de procariotas. Están constituidos por dos hélices alfa conectadas por una cadena corta de aminoácidos, lo que constituye el "giro". Ambas hélices deben mantener un ángulo determinado, principalmente por las interacciones entre ellas. (Traducción libre del original: Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Descriptor Portuguese: Sequências Hélice-Volta-Hélice
Descriptor French: Motifs à hélice-tour-hélice
Entry term(s): HTH Motif
HTH Motifs
Helix Turn Helix Motifs
Helix-Turn-Helix Motif
Motif, HTH
Motif, Helix-Turn-Helix
Motifs, HTH
Motifs, Helix Turn Helix
Motifs, Helix-Turn-Helix
Tree number(s): G02.111.570.820.709.275.500.360.360
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019077
Scope note: The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Annotation: do not confuse with HELIX-LOOP-HELIX MOTIFS
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Amino Acid Sequence (1985-1994)
Helix-Loop-Helix Motifs (1994-1995)
Public MeSH Note: 96; was see HELIX-LOOP-HELIX MOTIFS 1994-95
Online Note: use HELIX-LOOP-HELIX MOTIFS to search HELIX-TURN-HELIX MOTIFS 1994-95
History Note: 96; was see HELIX-LOOP-HELIX MOTIFS 1994-95
DeCS ID: 32734
Unique ID: D019077
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2016/05/31
Helix-Turn-Helix Motifs - Preferred
Concept UI M0028477
Scope note The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Preferred term Helix-Turn-Helix Motifs
Entry term(s) HTH Motif
HTH Motifs
Helix Turn Helix Motifs
Helix-Turn-Helix Motif
Motif, HTH
Motif, Helix-Turn-Helix
Motifs, HTH
Motifs, Helix Turn Helix
Motifs, Helix-Turn-Helix



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