DeCS

Descriptor English:

ETS Motif

Descriptor Spanish:

Motivo ETS

Spanish from Spain

Descriptor	motivo ETS
Entry term(s)	dominio ETS
Scope note:	Motivo hélice-giro-hélice caracterizado por tres hélices alfa y cuatro láminas beta de cuatro hebras colocadas en el siguiente orden: alfa1-beta1-beta2-alfa2-alfa3-beta3-beta4; la tercera hélice alfa está en contacto con el surco mayor del ADN. El motivo ETS y las secuencias de aminoácidos adyacentes de las proteínas ETS influyen en la afinidad de unión, y el cambio de un solo aminoácido del dominio ETS puede cambiar su especificad de unión al ADN.

Descriptor Portuguese:

Motivo ETS

Descriptor French:

Motif ETS

Entry term(s):

ETS Domain
ETS Domains
ETS Motifs
Helix Turn Helix, ETS Type Domain Containing
Helix-Turn-Helix, ETS-Type Domain Containing

Tree number(s):

G02.111.570.820.709.275.500.360.360.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000071419

Scope note:

A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.

Allowable Qualifiers:

DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects

Previous Indexing:

Amino Acid Sequence (1990-2016)
Proto-Oncogene Proteins (1990-2016)
Transcription Factors (1990-2016)

Public MeSH Note:

2017

History Note:

2017

Proto-Oncogene Protein c-ets-1 MeSH

DeCS ID:

56730

Unique ID:

D000071419

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

2017/01/01

Date of Entry:

2016/07/08

Revision Date:

2016/05/09

PHENOMENA AND PROCESSES

Chemical Phenomena [G02]

Chemical Phenomena

Biochemical Phenomena [G02.111]

Biochemical Phenomena

Molecular Structure [G02.111.570]

Molecular Structure

Molecular Conformation [G02.111.570.820]

Molecular Conformation

Protein Conformation [G02.111.570.820.709]

Protein Conformation

Protein Structural Elements [G02.111.570.820.709.275]

Protein Structural Elements

Amino Acid Motifs [G02.111.570.820.709.275.500]

Amino Acid Motifs

Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]

Helix-Loop-Helix Motifs

Helix-Turn-Helix Motifs [G02.111.570.820.709.275.500.360.360]

Helix-Turn-Helix Motifs

ETS Motif [G02.111.570.820.709.275.500.360.360.500]

ETS Motif

ETS Motif - Preferred

Concept UI	M000614527
Scope note	A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.
Preferred term	ETS Motif
Entry term(s)	ETS Domain ETS Domains ETS Motifs Helix Turn Helix, ETS Type Domain Containing Helix-Turn-Helix, ETS-Type Domain Containing

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