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Descriptor English: Cystic Fibrosis Transmembrane Conductance Regulator
Descriptor Spanish: Regulador de Conductancia de Transmembrana de Fibrosis Quística
Descriptor Portuguese: Regulador de Condutância Transmembrana em Fibrose Cística
Descriptor French: Protéine CFTR
Entry term(s): CFTR Protein
Chloride channels, ATP gated CFTR
Chloride channels, ATP-gated CFTR
Protein, CFTR
Tree number(s): D12.776.157.530.100.304.500
D12.776.157.530.400.175.125
D12.776.157.530.450.074.500.500.500.500
D12.776.543.550.450.175.125
D12.776.543.585.100.304.500
D12.776.543.585.400.175.125
D12.776.543.585.450.074.500.500.500.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019005
Scope note: A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 126880-72-6
Previous Indexing: Membrane Proteins (1989-1995)
Public MeSH Note: 96; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR was indexed under MEMBRANE PROTEINS 1989-95
Online Note: use CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (NM) to search CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 1989-95
History Note: 96; was CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (NM) 1989-95
DeCS ID: 32784
Unique ID: D019005
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/24
Revision Date: 2016/07/01
Cystic Fibrosis Transmembrane Conductance Regulator - Preferred
Concept UI M0028383
Scope note A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
Preferred term Cystic Fibrosis Transmembrane Conductance Regulator
Entry term(s) CFTR Protein
Chloride channels, ATP gated CFTR
Chloride channels, ATP-gated CFTR
Protein, CFTR



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