| Descriptor English: | Multidrug Resistance-Associated Proteins | ||||||
| Descriptor Spanish: |
Proteínas Asociadas a Resistencia a Múltiples Medicamentos
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| Descriptor Portuguese: | Proteínas Associadas à Resistência a Múltiplos Medicamentos | ||||||
| Descriptor French: | Protéines associées à la multirésistance aux médicaments | ||||||
| Entry term(s): |
ATP Binding Cassette, Sub Family C Proteins ATP-Binding Cassette, Sub-Family C Proteins MOAT Protein Multidrug Resistance Associated Protein Multidrug Resistance Associated Proteins Multidrug Resistance-Associated Protein Multispecific Organic Anion Transport Proteins Multispecific Organic Anion Transporter Resistance-Associated Protein, Multidrug |
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| Tree number(s): |
D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D027425 | ||||||
| Scope note: | A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
P-Glycoprotein (1987-2001) |
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| Public MeSH Note: | 2002; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN was indexed under ABC TRANSPORTERS 1994-2001; MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER were indexed under CARRIER PROTEINS 1995-2001 |
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| History Note: | 2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001 |
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| Entry Version: | MULTIDRUG RESISTANCE ASSOC PROTEINS |
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| Related: |
ATP Binding Cassette Transporter, Subfamily B
MeSH Drug Resistance, Multiple MeSH | ||||||
| DeCS ID: | 36147 | ||||||
| Unique ID: | D027425 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2002/01/01 | ||||||
| Date of Entry: | 2001/07/25 | ||||||
| Revision Date: | 2018/07/13 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Multidrug Resistance-Associated Proteins
- Preferred
| Concept UI |
M0238823 |
| Scope note | A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins. |
| Preferred term | Multidrug Resistance-Associated Proteins |
| Entry term(s) |
ATP Binding Cassette, Sub Family C Proteins ATP-Binding Cassette, Sub-Family C Proteins MOAT Protein Multidrug Resistance Associated Protein Multidrug Resistance Associated Proteins Multidrug Resistance-Associated Protein Multispecific Organic Anion Transport Proteins Multispecific Organic Anion Transporter Resistance-Associated Protein, Multidrug |
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