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Descriptor English: Integrases
Descriptor Spanish: Integrasas
Descriptor integrasas
Entry term(s) integrasa
Scope note: Recombinasas que insertan ADN exógeno en el genoma del hospedador. Algunos ejemplos son las proteínas codificadas por los GENES POL de los RETROVIRIDAE y también por los BACTERIÓFAGOS templados, de los que el más conocido es el BACTERIÓFAGO LAMBDA. 
Descriptor Portuguese: Integrases
Descriptor French: Integrases
Entry term(s): Integrase
Tree number(s): D08.811.739.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019426
Scope note: Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.
Annotation: HIV INTEGRASE is also available
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Integrase Inhibitors
Registry Number: EC 2.7.7.-
Previous Indexing: Coliphages/enzymology (1974-1980)
DNA Helicases (1974-1987)
DNA Nucleotidyltransferases (1974-1996)
Viral Proteins (1980-1987)
Public MeSH Note: 2004; see INTEGRASE 1997-2003; INTEGRASE was indexed under DNA NUCLEOTIDYLTRANSFERASES 1974-96, DNA UNWINDING PROTEINS 1974-87, VIRAL PROTEINS 1980-87, & COLIPHAGES/enzymology 1974-80
History Note: 2004(1997); use INTEGRASE (NM) 1974-1996
DeCS ID: 33023
Unique ID: D019426
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/13
Revision Date: 2003/07/09
Integrases - Preferred
Concept UI M0028900
Scope note Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.
Preferred term Integrases
Entry term(s) Integrase



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