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Descriptor English: Endothelin-1
Descriptor Spanish: Endotelina-1
Descriptor endotelina 1
Scope note: Péptido de 21 aminoácidos producido en una variedad de tejidos que incluyen las células endoteliales y musculares lisas vasculares, neuronas y astrocitos en el sistema nervioso central y células endometriales. Actúa como modulador del tono vasomotor, proliferación celular y producción hormonal. (N Eng J Med 1995;333(6):356-63)
Descriptor Portuguese: Endotelina-1
Descriptor French: Endothéline-1
Entry term(s): Big Endothelin
Big Endothelin 1
Big Endothelin-1
Endothelin 1
Endothelin Type 1
Endothelin, Big
Endothelin-1, Big
Precursor, Proendothelin-1
Preproendothelin
Preproendothelin 1
Preproendothelin-1
Proendothelin (1-38)
Proendothelin 1 Precursor
Proendothelin-1 Precursor
Tree number(s): D12.644.276.400.225
D12.776.467.400.225
D23.529.400.225
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019332
Scope note: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Annotation: /drug eff permitted
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Endothelins (1991-1996)
Public MeSH Note: 2004; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN was indexed under ENDTHELINS & PROTEIN PRECUSORS 1991-2003; under PEPTIDES 1990; PREPROENDOTHELIN was indexed under ENDOTHELINS & PROTEIN PRECUSORS 1989-2003
History Note: 2004(1997); use ENDOTHELINS 1991-96; for BIG ENDOTHELIN use ENDOTHELIN-1 (NM) 1990-2003; for PREPROENDOLTHELIN use ENDOTHELINS-1 (NM) 1989-2003
DeCS ID: 33036
Unique ID: D019332
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2015/06/26
Endothelin-1 - Preferred
Concept UI M0028780
Scope note A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Preferred term Endothelin-1
Entry term(s) Endothelin 1
Endothelin Type 1
Proendothelin (1-38) - Narrower
Concept UI M0174536
Scope note A 38 amino acid form of endothelin-1 that results from alternative processing of proendothelin-1.
Preferred term Proendothelin (1-38)
Entry term(s) Big Endothelin
Big Endothelin 1
Big Endothelin-1
Endothelin, Big
Endothelin-1, Big
Preproendothelin-1 - Narrower
Concept UI M0167677
Preferred term Preproendothelin-1
Entry term(s) Precursor, Proendothelin-1
Preproendothelin
Preproendothelin 1
Proendothelin 1 Precursor
Proendothelin-1 Precursor



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