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Descriptor English: Endothelin-3
Descriptor Spanish: Endotelina-3
Descriptor endotelina 3
Scope note: Péptido de 21 aminoácidos que circula en el plasma, pero cuyo origen es desconoce. Se ha encontrado la endotelina 3 en elevadas concentraciones en el cerebro y puede regular funciones importantes de las neuronas y astrocitos, como la proliferación y el desarrollo. Se encuentra también en el tracto gastrointestinal y en el pulmón y riñón. (N Eng J Med 1995;333(6):356-63)
Descriptor Portuguese: Endotelina-3
Descriptor French: Endothéline-3
Entry term(s): Big Endothelin 3
Big Endothelin-3
Endothelin 3
Endothelin 3, Big
Endothelin-3, Big
Tree number(s): D12.644.276.400.245
D12.776.467.400.245
D23.529.400.245
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019334
Scope note: A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Endothelins (1991-1996)
Public MeSH Note: 1997; see ENDOTHELINS 1991-1996; BIG ENDOTHELIN 3 was indexed under ENDOTHELINS & PROTEIN PRECURSORS 1993-2003
History Note: 1997; use ENDOTHELINS 1991-1996; for BIG ENDOTHELIN 3 use ENDOTHELIN-3 (NM) 1993-2003
DeCS ID: 33038
Unique ID: D019334
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2007/07/09
Endothelin-3 - Preferred
Concept UI M0028782
Scope note A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)
Preferred term Endothelin-3
Entry term(s) Endothelin 3
Big Endothelin 3 - Narrower
Concept UI M0219571
Scope note An alternatively processed form of endothelin-3 that is larger in size.
Preferred term Big Endothelin 3
Entry term(s) Big Endothelin-3
Endothelin 3, Big
Endothelin-3, Big



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