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Descriptor English: Genistein
Descriptor Spanish: Genisteína
Descriptor genisteína
Scope note: Isoflavonoide derivado de los productos de la soja. Inhibe la PROTEÍNA-TIROSINA QUINASA y la actividad de la topoisomerasa-II (TOPOISOMERASAS DEL ADN DE TIPO II). Se utiliza como agente antineoplásico y antitumoral. Experimentalmente, se ha demostrado que induce la interrupción de la FASE G2 en lineas celulares humanas y murinas e inhibe la PROTEÍNA-TIROSINA QUINASA.
Descriptor Portuguese: Genisteína
Descriptor French: Génistéine
Entry term(s): Genestein
Tree number(s): D03.383.663.283.266.450.400.375
D03.633.100.150.266.450.400.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019833
Scope note: An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticarcinogenic Agents
Protein Kinase Inhibitors
Phytoestrogens
Registry Number: DH2M523P0H
Previous Indexing: Isoflavones (1976-1997)
Public MeSH Note: 98; GENISTEIN was indexed under ISOFLAVONES 1976-97
History Note: 98; use GENISTEIN (NM) 1980-97
DeCS ID: 33414
Unique ID: D019833
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2016/05/31
Genistein - Preferred
Concept UI M0029441
Scope note An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
Preferred term Genistein
Entry term(s) Genestein



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