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Descriptor English: Heparin Lyase
Descriptor Spanish: Liasa de Heparina
Descriptor heparina liasa
Entry term(s) heparina eliminasa
heparinasa
heparinasa I
Scope note: Enzima de la clase isomerasa que cataliza la escisión eliminadora de polisacáridos que contienen residuos D-glucuronato o L-iduronato enlazados en 1,4 y residuos 2-sulfoamino-2-desoxi-6-sulfo-D-glucosa en enlaces 1,4-alfa, dando lugar a oligosacáridos con grupos terminales 4-desoxi-alfa-D-glucosa-4-enuronosil, en sus extremos no reductores. (Enzyme Nomenclature, 1992) EC 4.2.2.7.
Descriptor Portuguese: Heparina Liase
Descriptor French: Heparin lyase
Entry term(s): Eliminase, Heparin
Heparin Eliminase
Heparinase
Heparinase I
Lyase, Heparin
Neutralase
Tree number(s): D08.811.520.241.700.512
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019763
Scope note: An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.2.2.7
CAS Type 1 Name: heparin lyase
Previous Indexing: Heparin (1973-1982)
Lyases (1973-1979)
Polysaccharide-Lyases (1975-1997)
Public MeSH Note: 98; HEPARIN LYASE was indexed under POLYSACCHARIDE-LYASES 1975-97, HEPARIN 1973-82 & LYASES 1973-79
History Note: 98; use HEPARIN LYASE (NM) 1973-97
DeCS ID: 33452
Unique ID: D019763
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/25
Revision Date: 2016/06/28
Heparin Lyase - Preferred
Concept UI M0029324
Scope note An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.
Preferred term Heparin Lyase
Entry term(s) Eliminase, Heparin
Heparin Eliminase
Heparinase
Heparinase I
Lyase, Heparin
Neutralase



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