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Descriptor English: Mitogen-Activated Protein Kinase 1
Descriptor Spanish: Proteína Quinasa 1 Activada por Mitógenos
Descriptor proteína cinasa activada por mitógenos 1
Entry term(s) MAP cinasa 2
cinasa 2 regulada por señales extracelulares
cinasa regulada por señales extracelulares 2
p42 MAP cinasa
p42 MAPK
p42(proteína cinasa activada por mitógenos)
proteína cinasa 1 activada por mitógenos
proteína cinasa 2 activada por mitógenos
Scope note: Proteína serina/treonina dirigida por prolina que media en la transducción de señales desde la superificie celular al núcleo. La activación de la enzima por fosforilación lleva a su translocación al interior del núcleo, en donde actúa sobre factores de transcripción específicos. p40 MAPK y p41 MAPK son isoformas.
Descriptor Portuguese: Proteína Quinase 1 Ativada por Mitógeno
Descriptor French: Mitogen-Activated Protein Kinase 1
Entry term(s): Extracellular Signal Regulated Kinase 2
Extracellular Signal-Regulated Kinase 2
MAP Kinase 2
MAP Kinase, p42
MAPK1 Mitogen Activated Protein Kinase
MAPK1 Mitogen-Activated Protein Kinase
MAPK2 Mitogen Activated Protein Kinase
MAPK2 Mitogen-Activated Protein Kinase
Mitogen Activated Protein Kinase 1
Mitogen Activated Protein Kinase 2
Mitogen-Activated Protein Kinase 2
p42 MAP Kinase
p42 MAPK
p42(Mapk)
p42(Mapk) Kinase
p42(Mitogen-Activated Protein Kinase)
Tree number(s): D08.811.913.696.620.682.700.567.249.500
D12.776.476.563.567.249.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019950
Scope note: A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Annotation: Don't confuse MAP Kinase 2 with MAP KINASE KINASES referred to as MAP2 Kinases
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.24
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1997)
Protein Kinases (1992)
Protein-Serine-Threonine Kinases (1993-1995)
Protein-Tyrosine Kinase (1992-1997)
Public MeSH Note: 2000; see P42 MAP KINASE 2000-2004, see P42(MAPK) KINASE 1998-1999; P42(MAPK) KINASE was indexed under CALMODULIN-DEPENDENT PROTEIN KINASES 1994-1997, PROTEIN-TYROSINE KINASE 1992-1997, PROTEIN-SERINE-THREONINE KINASES 1993-1995 & PROTEIN KINASES 1992; ERK2 BRAIN KINASE PK40 was indexed under PROTEIN-SERINE-THREONINE KINASES 1995-1999; ERK2 was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999, CALMODULIN-DEPENDENT KINASES 1994-1997, PROTEIN-SERINE-THREONINE KINASES 1992-1993 & PROTEIN KINASES 1992; ERK2 MBP-KINASE was indexed under CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE 1998-1999 & CALMODULIN-DEPENDENT KINASES 1994-1997
History Note: 2005(1992)
DeCS ID: 33471
Unique ID: D019950
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/07/02
Revision Date: 2015/11/24
Mitogen-Activated Protein Kinase 1 - Preferred
Concept UI M0029623
Scope note A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
Preferred term Mitogen-Activated Protein Kinase 1
Entry term(s) Extracellular Signal Regulated Kinase 2
Extracellular Signal-Regulated Kinase 2
MAP Kinase 2
MAP Kinase, p42
MAPK1 Mitogen Activated Protein Kinase
MAPK1 Mitogen-Activated Protein Kinase
MAPK2 Mitogen Activated Protein Kinase
MAPK2 Mitogen-Activated Protein Kinase
Mitogen Activated Protein Kinase 1
Mitogen Activated Protein Kinase 2
Mitogen-Activated Protein Kinase 2
p42 MAP Kinase
p42 MAPK
p42(Mapk)
p42(Mapk) Kinase
p42(Mitogen-Activated Protein Kinase)



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