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Descriptor English: Trinucleotide Repeat Expansion
Descriptor Spanish: Expansión de Repetición de Trinucleótido
Descriptor expansión de repeticiones de trinucleótidos
Scope note: Aumento del número de repeticiones de trinucleótidos contiguos en la secuencia de ADN de una generación a otra. La presencia de estas regiones se asocia a enfermedades como el SÍNDROME DEL CROMOSOMA X FRÁGIL y la DISTROFIA MIOTÓNICA. Algunos SITIOS FRÁGILES DEL CROMOSOMA contienen secuencias en las que se producen expansiones de repeticiones de trinucleótidos.
Descriptor Portuguese: Expansão das Repetições de Trinucleotídeos
Descriptor French: Expansion de trinucléotide répété
Entry term(s): Expanded Trinucleotide Repeat
Expanded Trinucleotide Repeats
Expansion, Trinucleotide Repeat
Expansions, Trinucleotide Repeat
Repeat Expansion, Trinucleotide
Repeat Expansions, Trinucleotide
Repeat, Expanded Trinucleotide
Repeats, Expanded Trinucleotide
Trinucleotide Repeat Expansions
Trinucleotide Repeat, Expanded
Trinucleotide Repeats, Expanded
Tree number(s): G02.111.570.080.708.800.140.865
G02.111.570.080.708.800.500.850.200
G05.360.080.708.800.074.865
G05.360.080.708.800.500.850.200
G05.360.340.024.189.220.865
G05.360.340.024.850.500.850.200
G05.365.590.220.865
G05.558.220.865
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019680
Scope note: An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Repetitive Sequences, Nucleic Acid (1981-1997)
Public MeSH Note: 99; see DNA SEQUENCE, UNSTABLE 1998
History Note: 99(98)
Related: Anticipation, Genetic MeSH
Chromosome Fragile Sites MeSH
Chromosome Fragility MeSH
Fragile X Syndrome MeSH
Myotonic Dystrophy MeSH
DeCS ID: 33609
Unique ID: D019680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2016/06/17
Trinucleotide Repeat Expansion - Preferred
Concept UI M0029211
Scope note An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
Preferred term Trinucleotide Repeat Expansion
Entry term(s) Expanded Trinucleotide Repeat
Expanded Trinucleotide Repeats
Expansion, Trinucleotide Repeat
Expansions, Trinucleotide Repeat
Repeat Expansion, Trinucleotide
Repeat Expansions, Trinucleotide
Repeat, Expanded Trinucleotide
Repeats, Expanded Trinucleotide
Trinucleotide Repeat Expansions
Trinucleotide Repeat, Expanded
Trinucleotide Repeats, Expanded



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