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Descriptor in English: Chromosome Fragile Sites
Descriptor in Spanish: Sitios Frágiles del Cromosoma
Descriptor in Portuguese: Sítios Frágeis do Cromossomo
Descriptor in French: Sites fragiles de chromosome
Entry term(s): Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile
Tree number(s): G05.360.340.024.189.610
Scope note: Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
History Note: 2004; use CHROMOSOME FRAGILITY 1982-2003
See also the descriptors: Chromosome Fragility MeSH
DNA Repeat Expansion MeSH
Fragile X Syndrome MeSH
DeCS UI: 38395
Descriptor UI: D043283
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09
Chromosome Fragile Sites - Preferred
Concept UI M0004412
Scope note Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Preferred term Chromosome Fragile Sites
Entry term(s) Chromosome Fragile Site
Fragile Site, Chromosome
Fragile Sites, Chromosome
Site, Chromosome Fragile
Sites, Chromosome Fragile



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