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Descriptor English: N-Acetylgalactosamine-4-Sulfatase
Descriptor Spanish: N-Acetilgalactosamina-4-Sulfatasa
Descriptor n-acetilgalactosamina-4-sulfatasa
Entry term(s) arilsulfatasa B
Scope note: Arilsulfatasa que cataliza la hidrólisis de grupos 4-sulfato de las unidades de N-acetil-D-galactosamina 4-sulfato del sulfato de condroitina y del sulfato de dermatán. La deficiencia de esta enzima causa un trastorno lisosómico hereditario, el síndrome de Maroteax-Lamy (MUCOPOLISACARIDOSIS VI). EC 3.1.6.12.
Descriptor Portuguese: N-Acetilgalactosamina-4-Sulfatase
Descriptor French: N-acetylgalactosamine-4-sulfatase
Entry term(s): 4-Sulfatase, N-Acetylgalactosamine
Arylsulfatase B
Arylsulfatase B1
Arylsulfatase B2
B1, Arylsulfatase
B2, Arylsulfatase
N Acetylgalactosamine 4 Sulfatase
N Acetylgalactosamine 4 sulfate Sulfatase
N Acetylgalactosamine 4 sulphate Sulphatase
N-Acetylgalactosamine 4-Sulfatase
N-Acetylgalactosamine-4-sulfate Sulfatase
N-Acetylgalactosamine-4-sulphate Sulphatase
Sulfatase, N-Acetylgalactosamine-4-sulfate
Sulphatase, N-Acetylgalactosamine-4-sulphate
Tree number(s): D08.811.277.352.827.070.060
D08.811.277.352.827.180.175.060
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020051
Scope note: An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Mucopolysaccharidosis VI
Registry Number: EC 3.1.6.12
CAS Type 1 Name: N-Acetyl-D-Galactosamine-4-sulfate 4-sulfohydrolase
Previous Indexing: Sulfatases (1988-1998)
Public MeSH Note: 99; for ARYLSULFATASE B see CHONDRO-4-SULFATASE 1975-98; N-ACETYLGALACTOSAMINE-4-SULFATE SULFATASE (now N-ACETYLGALACTOSAMINE-4-SULFATASE) was indexed under SULFATASES 1988-98
History Note: 99; for ARYLSULFATASE B use CHONDRO-4-SULFATASE 1975-98; use N-ACETYLGALACTOSAMINE-4-SULFATASE (NM) 1988-98
DeCS ID: 33824
Unique ID: D020051
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2016/06/28
N-Acetylgalactosamine-4-Sulfatase - Preferred
Concept UI M0029765
Scope note An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Preferred term N-Acetylgalactosamine-4-Sulfatase
Entry term(s) 4-Sulfatase, N-Acetylgalactosamine
Arylsulfatase B
N Acetylgalactosamine 4 Sulfatase
N Acetylgalactosamine 4 sulfate Sulfatase
N Acetylgalactosamine 4 sulphate Sulphatase
N-Acetylgalactosamine 4-Sulfatase
N-Acetylgalactosamine-4-sulfate Sulfatase
N-Acetylgalactosamine-4-sulphate Sulphatase
Sulfatase, N-Acetylgalactosamine-4-sulfate
Sulphatase, N-Acetylgalactosamine-4-sulphate
Arylsulfatase B2 - Narrower
Concept UI M0029764
Preferred term Arylsulfatase B2
Entry term(s) B2, Arylsulfatase
Arylsulfatase B1 - Narrower
Concept UI M0029763
Preferred term Arylsulfatase B1
Entry term(s) B1, Arylsulfatase



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