PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena RNA Processing, Post-Transcriptional [G02.111.760] RNA Processing, Post-Transcriptional RNA Splicing [G02.111.760.700] RNA Splicing Alternative Splicing [G02.111.760.700.100] Alternative Splicing Trans-Splicing [G02.111.760.700.750] Trans-Splicing PHENOMENA AND PROCESSES Metabolism [G03] Metabolism RNA Processing, Post-Transcriptional [G03.839] RNA Processing, Post-Transcriptional RNA Splicing [G03.839.700] RNA Splicing Alternative Splicing [G03.839.700.100] Alternative Splicing Trans-Splicing [G03.839.700.750] Trans-Splicing PHENOMENA AND PROCESSES Genetic Phenomena [G05] Genetic Phenomena Gene Expression Regulation [G05.308] Gene Expression Regulation RNA Processing, Post-Transcriptional [G05.308.700] RNA Processing, Post-Transcriptional RNA Splicing [G05.308.700.700] RNA Splicing Alternative Splicing [G05.308.700.700.100] Alternative Splicing Trans-Splicing [G05.308.700.700.750] Trans-Splicing

Trans-Splicing - Preferred

Concept UI	M0029753
Scope note	The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Preferred term	Trans-Splicing
Entry term(s)	RNA Splicing, Trans RNA Trans Splicing RNA Trans-Splicing Splicing, Trans Trans RNA Splicing Trans Splicing Trans-Splicings, RNA