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Descriptor English: Selective Estrogen Receptor Modulators
Descriptor Spanish: Moduladores Selectivos de los Receptores de Estrógeno
Descriptor moduladores selectivos de los receptores de estrógenos
Entry term(s) MSRE
moduladores selectivos de los receptores estrogénicos
moduladores selectivos de receptores de estrógenos
moduladores selectivos de receptores estrogénicos
Scope note: Grupo estructuralmente diverso de compuestos que se distinguen de los ESTRÓGENOS por su capacidad para unirse y activar a los RECEPTORES DE ESTRÓGENOS, pero actúan o como agonistas o como antagonistas del estrógeno, dependiendo del tipo de tejido y medio hormonal. Se clasifican como de primera generación, si poseen propiedades agonistas del estrógeno en el ENDOMETRIO, o de segunda generación, sobre la base de sus patrones de especificidad tisular. (Horm Res 1997;48:155-63)"
Descriptor Portuguese: Moduladores Seletivos de Receptor Estrogênico
Descriptor French: Modulateurs sélectifs des récepteurs des oestrogènes
Entry term(s): Estrogen Receptor Modulator, Selective
Estrogen Receptor Modulators, Selective
SERM
SERMs
Selective Estrogen Receptor Modulator
Tree number(s): D06.347.360.827
D27.505.696.399.450.360.827
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020845
Scope note: A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Annotation: do not confuse with ESTROGEN RECEPTOR MODULATORS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Receptors, Estrogen (1996-1999)
Public MeSH Note: 2000
History Note: 2000
Entry Version: SELECTIVE ESTROGEN RECEPT MODULATORS
Related: Bone Density Conservation Agents MeSH
DeCS ID: 34403
Unique ID: D020845
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2013/07/09
Selective Estrogen Receptor Modulators - Preferred
Concept UI M0328354
Scope note A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Preferred term Selective Estrogen Receptor Modulators
Entry term(s) Estrogen Receptor Modulator, Selective
Estrogen Receptor Modulators, Selective
SERM
SERMs
Selective Estrogen Receptor Modulator



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