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Descriptor English: Tacrolimus Binding Protein 1A
Descriptor Spanish: Proteína 1A de Unión a Tacrolimus
Descriptor proteína 1A de unión al tacrolimús
Entry term(s) FKBP12
proteína 1A de unión a FK506
Scope note: Proteína de unión al tacrolimús, de 12 KDa, que se encuentra asociada con los canales de liberación de calcio y modulan la función de dichos canales. Es una peptidil-prolil cis-trans isomerasa que resulta inhibida por el tacrolimús (comúnmente llamado FK506) y el SIROLIMÚS.
Descriptor Portuguese: Proteína 1A de Ligação a Tacrolimo
Descriptor French: Protéine 1A de liaison au tacrolimus
Entry term(s): FK506 Binding Protein 1
FK506 Binding Protein 1A
FK506-Binding Protein 1
FK506-Binding Protein 1A
FKBP 12
FKBP-12
FKBP12
Macrophilin 12
Macrophilin-12
Tree number(s): D08.811.399.325.500.400.700.500
D12.776.543.750.705.400.700.500
D12.776.827.344.700.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D022061
Scope note: A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 5.2.1.-
Previous Indexing: Carrier Proteins (1991-1998)
DNA-Binding Proteins (1991-1998)
Heat-Shock Proteins (1991-1998)
Immunophilins (1999-2000)
Public MeSH Note: 2001; FK 506 BINDING PROTEIN (now TACROLIMUS BINDING PROTEINS) was indexed under IMMUNOPHILINS 1999-2000 & under HEAT-SHOCK PROTEINS, DNA-BINDING PROTEINS, & CARRIER PROTEINS 1991-1998
History Note: 2001; use TACROLIMUS BINDING PROTEINS (NM) 1991-2000
DeCS ID: 35327
Unique ID: D022061
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2001/01/01
Date of Entry: 2000/06/23
Revision Date: 2004/08/02
Tacrolimus Binding Protein 1A - Preferred
Concept UI M0182872
Scope note A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of calcium release channels. It is a peptidyl-prolyl cis/trans isomerase which is inhibited by both tacrolimus (commonly called FK506) and SIROLIMUS.
Preferred term Tacrolimus Binding Protein 1A
Entry term(s) FK506 Binding Protein 1
FK506 Binding Protein 1A
FK506-Binding Protein 1
FK506-Binding Protein 1A
FKBP 12
FKBP-12
FKBP12
Macrophilin 12
Macrophilin-12



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