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Descriptor English: Immunophilins
Descriptor Spanish: Inmunofilinas
Descriptor inmunofilinas
Entry term(s) inmunofilina
neurofilinas
Scope note: Miembros de una familia de proteínas altamente conservadas todas ellas cis-trans peptidil-prolil isomerasas (PEPTIDILPROLIL ISOMERASA). Se unen a los fármacos inmunosupresores CICLOSPORINA, TACROLIMÚS y SIROLIMÚS. Poseen actividad rotomasa, que es inhibida por los fármacos inmunosupresores a los que se unen.
Descriptor Portuguese: Imunofilinas
Descriptor French: Immunophilines
Entry term(s): Immunophilin
Neurophilin
Neurophilins
Tree number(s): D08.811.399.325.500.400
D12.776.543.750.705.400
D12.776.827.344
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020104
Scope note: Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Annotation: don't confuse entry term NEUROPHILINS with NEUROPILINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 5.2.1.8
Previous Indexing: Immunosuppressive Agents (1990-1998)
Public MeSH Note: 2004; NEUROPHILIN was indexed under LYMPHOKINES 1974-2003; ENDOTHELIAL GROWTH FACTORS 1991-2003 & INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 2002
History Note: 2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
DeCS ID: 33828
Unique ID: D020104
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2020/05/27
Immunophilins - Preferred
Concept UI M0029838
Scope note Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Preferred term Immunophilins
Entry term(s) Immunophilin
Neurophilins - Related but not broader or narrower
Concept UI M0057218
Scope note Immunophilins found in the brain.
Preferred term Neurophilins
Entry term(s) Neurophilin



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