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Descriptor English: Cyclophosphamide
Descriptor Spanish: Ciclofosfamida
Descriptor ciclofosfamida
Scope note: Precursor de una mostaza nitrogenada alquilante, antineoplásica e inmunosupresora que es activada en el HÍGADO dando lugar a la forma activa aldofosfamida. Se ha utilizado en el tratamiento de LINFOMAS y LEUCEMIAS. Su efecto colateral, la ALOPECIA, ha sido aprovechado para el esquilado de las ovejas. La ciclofosfamida también puede producir esterilidad, malformaciones congénitas, mutaciones y cáncer.
Descriptor Portuguese: Ciclofosfamida
Descriptor French: Cyclophosphamide
Entry term(s): (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate
B 518
B-518
B518
Cyclophosphamide Anhydrous
Cyclophosphamide Monohydrate
Cyclophosphamide, (R)-Isomer
Cyclophosphamide, (S)-Isomer
Cyclophosphane
Cytophosphan
Cytophosphane
Cytoxan
Endoxan
NSC 26271
NSC-26271
NSC26271
Neosar
Procytox
Sendoxan
Tree number(s): D02.455.526.728.650.730.243
D02.705.672.500.243
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003520
Scope note: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Immunosuppressive Agents
Mutagens
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Myeloablative Agonists
Registry Number: 8N3DW7272P
DeCS ID: 3540
Unique ID: D003520
NLM Classification: QV 269
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2018/05/21
Cyclophosphamide - Preferred
Concept UI M0005485
Scope note Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Preferred term Cyclophosphamide
Sendoxan - Narrower
Concept UI M0005490
Preferred term Sendoxan
B-518 - Narrower
Concept UI M0369305
Preferred term B-518
Entry term(s) B 518
B518
Cyclophosphamide Anhydrous - Narrower
Concept UI M0585642
Preferred term Cyclophosphamide Anhydrous
Cyclophosphamide, (R)-Isomer - Narrower
Concept UI M0331230
Preferred term Cyclophosphamide, (R)-Isomer
Cyclophosphamide, (S)-Isomer - Narrower
Concept UI M0331229
Preferred term Cyclophosphamide, (S)-Isomer
Cytophosphane - Narrower
Concept UI M000638429
Preferred term Cytophosphane
Cyclophosphamide Monohydrate - Narrower
Concept UI M000638430
Preferred term Cyclophosphamide Monohydrate
Cytophosphan - Narrower
Concept UI M0582317
Preferred term Cytophosphan
Cytoxan - Related but not broader or narrower
Concept UI M0005486
Preferred term Cytoxan
Endoxan - Narrower
Concept UI M0005487
Preferred term Endoxan
Neosar - Narrower
Concept UI M0005488
Preferred term Neosar
NSC-26271 - Narrower
Concept UI M0369304
Preferred term NSC-26271
Entry term(s) NSC 26271
NSC26271
Procytox - Narrower
Concept UI M0005489
Preferred term Procytox
(+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate - Narrower
Concept UI M000642260
Preferred term (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate
Cyclophosphane - Narrower
Concept UI M000638428
Preferred term Cyclophosphane



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