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Descriptor English: Dapsone
Descriptor Spanish: Dapsona
Descriptor Portuguese: Dapsona
Descriptor French: Dapsone
Entry term(s): 4,4' Diaminophenyl Sulfone
4,4'-Diaminophenyl Sulfone
Avlosulfone
DADPS
Dapsoderm-X
Dapson-Fatol
Diaminodiphenylsulfone
Diaphenylsulfone
Disulone
Sulfona
Sulfone, 4,4'-Diaminophenyl
Sulfonyldianiline
Tree number(s): D02.886.590.263
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003622
Scope note: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Infective Agents
Antimalarials
Folic Acid Antagonists
Leprostatic Agents
Registry Number: 8W5C518302
DeCS ID: 3641
Unique ID: D003622
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05
Dapsone - Preferred
Concept UI M0005661
Scope note A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Preferred term Dapsone
Entry term(s) 4,4' Diaminophenyl Sulfone
4,4'-Diaminophenyl Sulfone
DADPS
Diaminodiphenylsulfone
Diaphenylsulfone
Sulfone, 4,4'-Diaminophenyl
Sulfonyldianiline
Sulfona - Narrower
Concept UI M0485005
Preferred term Sulfona
Dapson-Fatol - Narrower
Concept UI M0485006
Preferred term Dapson-Fatol
Disulone - Narrower
Concept UI M0372339
Preferred term Disulone
Avlosulfone - Narrower
Concept UI M0372340
Preferred term Avlosulfone
Dapsoderm-X - Narrower
Concept UI M0485007
Preferred term Dapsoderm-X



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