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Descriptor English: Neural Cell Adhesion Molecule L1
Descriptor Spanish: Molécula L1 de Adhesión de Célula Nerviosa
Descriptor molécula L1 de adhesión de células nerviosas
Scope note: Miembro de la superfamilia de inmunoglobulinas de las moléculas de adhesión de las células neuronales, necesario para el desarrollo apropiado del sistema nervioso. Consta de seis dominios de Ig, cinco dominios de fibronectina, una región transmembranaria y un dominio intracelular. Se conocen dos variantes de ayuste: una forma neuronal que contiene una secuencia RSLE de cuatro aminoácidos en el dominio citoplásmico, y una forma no neuronal en la que falta la secuencia RSLE. Las mutaciones del gen L1 dan lugar a la enfermedad L1. La molécula L1 de adhesión de la célula neural se manifiesta predominantemente durante el desarrollo de las neuronas y de las células de Schwann; está implicada en la adherencia celular, migración neuronal, crecimiento y exploración axónicos y en la mielinización.
Descriptor Portuguese: Molécula L1 de Adesão de Célula Nervosa
Descriptor French: Molécule d'adhérence cellulaire neurale L-1
Entry term(s): CALL Protein
CamL1 Gene Product
Cell Adhesion Molecule L1
Cell Surface Glycoprotein L1
F11 Glycoprotein
Glycoprotein, NGF-Inducible
Glycoprotein, NILE
L1 Cell Adhesion Molecule
L1CAM
NGF Inducible Glycoprotein
NGF-Inducible Glycoprotein
NILE Glycoprotein
NILE Protein
Nerve Growth Factor Inducible Large External Glycoprotein
Nerve Growth Factor-Inducible Large External Glycoprotein
Neural Adhesion Molecule L1
Tree number(s): D12.776.395.550.200.250.520.578
D12.776.543.550.200.250.520.578
D23.050.301.350.250.520.578
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039842
Scope note: A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antigens, Surface (1992-2002)
Cell Adhesion Molecules, Neuronal (1992-2002)
Membrane Glycoproteins (1992-2002)
Neural Cell Adhesion Molecules (1996-2002)
Public MeSH Note: 2003; NERVE GROWTH FACTOR-INDUCIBLE LARGE EXTERNAL GLYCOPROTEIN (now NEURAL CELL ADHESION MOLECULE L1) was indexed under MEMBRANE GLYCOPROTEINS 1988-2002 & GLYCOPROTEINS 1983-1987; NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 were indexed under MEMBRANE GLYCOPROTEINS 1992-2002, NEURAL CELL ADHESION MOLECULES 1996-2002, CELL ADHESION MOLECULES, NEURONAL 1992-1995 & ANTIGENS, SURFACE 1984-1991; CALL PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1999-2002 & NEURAL CELL ADHESION MOLECULES 1999-2002; NILE PROTEIN was indexed under MEMBRANE GLYCOPROTEINS 1992-2002 & NEURAL CELL ADHESION MOLECULES 1996-2002
History Note: 2003; use NEURAL CELL ADHESION MOLECULE L1 (NM) 1983-2002; for NEURAL CELL ADHESION MOLECULE L1; F11 GLYCOPROTEIN; CELL ADHESION MOLECULE L1; CAML1 GENE PRODUCT; CELL SURFACE GLYCOPROTEIN L1; L1 CELL ADHESION MOLECULE; L1 CAM & NEURAL ADHESION MOLECULE L1 use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1992-2002; for CALL PROTEIN use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1999-2002; for NILE PROTEIN use LEUCKCYTE L1 ANTIGEN COMPLEX (NM) 1996-2002
DeCS ID: 37447
Unique ID: D039842
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09
Neural Cell Adhesion Molecule L1 - Preferred
Concept UI M0122500
Scope note A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Preferred term Neural Cell Adhesion Molecule L1
Entry term(s) CALL Protein
CamL1 Gene Product
Cell Adhesion Molecule L1
Cell Surface Glycoprotein L1
F11 Glycoprotein
Glycoprotein, NGF-Inducible
Glycoprotein, NILE
L1 Cell Adhesion Molecule
L1CAM
NGF Inducible Glycoprotein
NGF-Inducible Glycoprotein
NILE Glycoprotein
NILE Protein
Nerve Growth Factor Inducible Large External Glycoprotein
Nerve Growth Factor-Inducible Large External Glycoprotein
Neural Adhesion Molecule L1



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