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Descriptor English: Neuroligins
Descriptor Spanish: Neuroliginas
Descriptor neuroliginas
Entry term(s) neuroligina
Scope note: Moléculas de adhesión celular postsinápticas que se unen a las NEUREXINAS presinápticas para formar adhesiones transinápticas dependientes de calcio. Las neuroliginas reclutan proteínas de andamiaje sináptico (p. ej., PSD-95) a través de su DOMINIO PDZ. La distribución e interacción con las neurexinas están reguladas por EMPALME ALTERNATIVO. Las alteraciones en los genes que codifican neuroliginas o neurexinas se asocian a enfermedades cognitivas como el TRASTORNO DEL ESPECTRO DEL AUTISMO.
Descriptor Portuguese: Neuroliginas
Descriptor French: Without translation
Entry term(s): Neuroligin
Tree number(s): D09.400.430.890.200.250.520.894
D12.776.395.550.200.250.520.894
D12.776.543.550.200.250.520.894
D12.776.631.641
D23.050.301.350.250.520.894
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000096785
Scope note: Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nerve Tissue Proteins (1992-2023)
Public MeSH Note: 2024
History Note: 2024
DeCS ID: 60519
Unique ID: D000096785
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/06/01
Neuroligins - Preferred
Concept UI M000762631
Scope note Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.
Preferred term Neuroligins
Entry term(s) Neuroligin



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