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Descriptor English: Histamine H1 Antagonists, Non-Sedating
Descriptor Spanish: Antagonistas de los Receptores Histamínicos H1 no Sedantes
Descriptor antagonistas de los receptores histamínicos H1 no sedantes
Entry term(s) antagonista H1 de segunda generación
antagonista H1 de tercera generación
antihistamínico de segunda generación
Scope note: Clase de fármacos no sedantes que se unen a los receptores de histamina pero no los activan (AGONISMO INVERSO DE FÁRMACOS), de modo que bloquean las acciones de la histamina o de los agonistas de la histamina. Estos antihistamínicos constituyen un grupo heterogéneo de compuestos con diferentes estructuras químicas, efectos adversos, distribución y metabolismo. En comparación con los antihistamínicos iniciales (primera generación), estos antihistamínicos no sedantes tienen mayor especificidad por el receptor y menor penetración de la BARRERA HEMATOENCEFÁLICA, y es menos probable que causen somnolencia o alteración psicomotriz.
Descriptor Portuguese: Antagonistas não Sedativos dos Receptores H1 da Histamina
Descriptor French: Antihistaminiques H1 non sédatifs
Entry term(s): Antihistamine, Second Generation
Antihistamines, Second Generation
Generation Antihistamine, Second
H1 Antihistamines, Non Sedating
H1 Antihistamines, Non-Sedating
Histamine H1 Antagonists, Non Sedating
Non-Sedating H1 Antihistamines
Second Generation Antihistamine
Second Generation Antihistamines
Second Generation H1 Antagonist
Second Generation H1 Antagonists
Third Generation H1 Antagonist
Third Generation H1 Antagonists
Tree number(s): D27.505.519.625.375.425.400.500
D27.505.696.577.375.425.400.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039563
Scope note: A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Benzhydryl Compounds (1982-2002)
Histamine H1 Antagonists (1982-2002)
Public MeSH Note: 2003
History Note: 2003
Entry Version: HISTAMINE H1 ANTAG NON SEDATING
Related: Anti-Allergic Agents MeSH
DeCS ID: 37547
Unique ID: D039563
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2020/05/27
Histamine H1 Antagonists, Non-Sedating - Preferred
Concept UI M0419330
Scope note A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Preferred term Histamine H1 Antagonists, Non-Sedating
Entry term(s) Antihistamine, Second Generation
Antihistamines, Second Generation
Generation Antihistamine, Second
H1 Antihistamines, Non Sedating
H1 Antihistamines, Non-Sedating
Histamine H1 Antagonists, Non Sedating
Non-Sedating H1 Antihistamines
Second Generation Antihistamine
Second Generation Antihistamines
Second Generation H1 Antagonist
Second Generation H1 Antagonists
Third Generation H1 Antagonists - Narrower
Concept UI M0503955
Scope note Active enantiomers and selective derivatives of second generation H1 antagonists.
Preferred term Third Generation H1 Antagonists
Entry term(s) Third Generation H1 Antagonist



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