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Descriptor English: Estrogenic Steroids, Alkylated
Descriptor Spanish: Esteroides Estrogénicos Alquilados
Descriptor esteroides estrogénicos alquilados
Scope note: ESTEROIDES estrogénicos con una cadena alifática en C17 u otra posición. La 17-alfa-ALQUILACIÓN hace que la molécula sea más estable y resistente a la degradación metabólica, además de mejorar la eficacia oral. Entre los estrógenos sintéticos alquilados se encuentran el ETINIL ESTRADIOL y el MESTRANOL. Las sustituciones en otros sitios confieren a los compuestos propiedades antiestrogénicas y citotóxicas.
Descriptor Portuguese: Esteroides Estrogênicos Alquilados
Descriptor French: Stéroïdes oestrogéniques à chaîne alkyle
Entry term(s): Alkyl Estrogenic Steroids
Alkylated Estrogenic Steroids
Tree number(s): D06.472.334.851.437.968
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D042782
Scope note: Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Estrogens
Previous Indexing: Ethinyl Estradiol (1968-2003)
Public MeSH Note: 2004
History Note: 2004
DeCS ID: 38106
Unique ID: D042782
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Estrogenic Steroids, Alkylated - Preferred
Concept UI M0441916
Scope note Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
Preferred term Estrogenic Steroids, Alkylated
Entry term(s) Alkyl Estrogenic Steroids
Alkylated Estrogenic Steroids



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