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Descriptor English: Angiopoietin-2
Descriptor Spanish: Angiopoyetina 2
Descriptor angiopoyetina 2
Scope note: Angiopoyetina estrechamente relacionada con la ANGIOPOYETINA 1. Se une al RECEPTOR TIE-2 sin estimulación del receptor y antagoniza el efecto de la ANGIOPOYETINA 1. Sin embargo, este efecto antagonista puede estar limitado a receptores celulares que se dan en los vasos sanguíneos. Por lo tanto, la angiopoyetina 2 puede desempeñar un papel en la disminución por regulación de los brotes y ramificaciones vasculares.
Descriptor Portuguese: Angiopoietina-2
Descriptor French: Angiopoïétine-2
Entry term(s): Angiopoietin 2
Tree number(s): D12.644.276.100.100.200
D12.776.467.100.100.200
D23.529.100.100.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D042702
Scope note: An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Angiogenesis Factor (2003)
Proteins (1999-2002)
Public MeSH Note: 2004; ANGIOPOIETIN-2 was indexed under PROTEINS 1999-2002 & ANGIOGENESIS FACTOR 2003
History Note: 2004; use ANGIOPOIETIN-2 (NM) 1997-2003
DeCS ID: 38239
Unique ID: D042702
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2006/07/05
Angiopoietin-2 - Preferred
Concept UI M0277968
Scope note An angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.
Preferred term Angiopoietin-2
Entry term(s) Angiopoietin 2



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