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Descriptor English: Laron Syndrome
Descriptor Spanish: Síndrome de Laron
Descriptor síndrome de Laron
Entry term(s) síndrome de insensibilidad a la hormona del crecimiento
Scope note: Trastorno autosómico recesivo caracterizado por estatura baja, alteración del RECEPTOR DE HORMONA DEL CRECIMIENTO e imposibilidad para producir el FACTOR I DEL CRECIMIENTO SIMILAR A LA INSULINA por la acción de la HORMONA DEL CRECIMIENTO. El síndrome de Laron no es una forma de enanismo hipofisario primario (ENANISMO POR DEFICIENCIA DE HORMONA DEL CRECIMIENTO) sino el resultado de la mutación del gen humano GHR en el cromosoma 5.
Descriptor Portuguese: Síndrome de Laron
Descriptor French: Syndrome de Laron
Entry term(s): Dwarfism II, Pituitary
Dwarfism IIs, Pituitary
Dwarfism, Laron
GH Resistance, Primary
Growth Hormone Insensitivity Syndrome
Growth Hormone Receptor Defect
Growth Hormone Receptor Deficiency
Laron Dwarfism
Laron Type Dwarfism I
Pituitary Dwarfism II
Pituitary Dwarfism IIs
Primary GH Resistance
Primary Growth Hormone Resistance
Severe GH Insensitivity
Syndrome, Laron
Tree number(s): C05.116.099.343.679
C16.320.240.750
C19.297.656
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D046150
Scope note: An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Dwarfism (1976-2004)
Growth Hormone (1976-2004)
Receptors, Cell Surface (1976-2004)
Receptors, Somatotropin (1991-2004)
Public MeSH Note: 2005
History Note: 2005
DeCS ID: 38609
Unique ID: D046150
NLM Classification: WK 550
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2012/07/03
Laron Syndrome - Preferred
Concept UI M0452907
Scope note An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.
Preferred term Laron Syndrome
Entry term(s) Dwarfism II, Pituitary
Dwarfism IIs, Pituitary
Dwarfism, Laron
GH Resistance, Primary
Growth Hormone Insensitivity Syndrome
Growth Hormone Receptor Defect
Growth Hormone Receptor Deficiency
Laron Dwarfism
Laron Type Dwarfism I
Pituitary Dwarfism II
Pituitary Dwarfism IIs
Primary GH Resistance
Primary Growth Hormone Resistance
Severe GH Insensitivity
Syndrome, Laron



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