| Descriptor English: | MAP Kinase Kinase 4 | ||||||
| Descriptor Spanish: |
MAP Quinasa Quinasa 4
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| Descriptor Portuguese: | MAP Quinase Quinase 4 | ||||||
| Descriptor French: | MAP Kinase Kinase 4 | ||||||
| Entry term(s): |
JN Kinase Kinase JNK Activating Protein Kinase JNK Kinase JNK-Activating Protein Kinase JNKK1 Protein Kinase Jun Amino Terminal Kinase Kinase Jun Amino-Terminal Kinase Kinase Kinase, JNKK1 Protein MEK4 Protein Kinase Mitogen Activated Protein Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinase 4 Protein Kinase, JNK-Activating Protein Kinase, JNKK1 Protein Kinase, MEK4 Protein Kinase, SEK1 SAP Kinase Extracellular Signal Regulated Kinase Kinase 1 SAP Kinase Kinase 1 SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 SAPK ERK Kinase 1 SAPK-ERK Kinase 1 SEK1 Protein Kinase Stress Activated Protein Kinase Kinase 1 Stress-Activated Protein Kinase Kinase 1 |
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| Tree number(s): |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.776.476.563.565.400 D12.776.476.568.200.400 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D048670 | ||||||
| Scope note: | A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.12.2 | ||||||
| Previous Indexing: |
Mitogen-Activated Protein Kinases (2000-2004) Protein-Serine-Threonine Kinases (1995-1999) Protein-Tyrosine Kinase (2000-2004) |
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| Public MeSH Note: | 2005; MAP KINASE KINASE 4 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES & PROTEIN-TYROSINE KINASE 2000-2004, & under PROTEIN-SERINE-THREONINE KINASES 1995-1999; JNK-ACTIVATING PROTEIN KINASE was indexed under JNK MITOGEN-ACTIVATED PROTEIN KINASES 2004-2005; under MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASES 2000-2005, & under PROTEIN KINASES 1995-1999 |
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| History Note: | 2005(1995) |
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| DeCS ID: | 38723 | ||||||
| Unique ID: | D048670 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2005/01/01 | ||||||
| Date of Entry: | 2004/07/07 | ||||||
| Revision Date: | 2015/11/24 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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MAP Kinase Kinase 4
- Preferred
| Concept UI |
M0240274 |
| Scope note | A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress. |
| Preferred term | MAP Kinase Kinase 4 |
| Entry term(s) |
JN Kinase Kinase JNK Activating Protein Kinase JNK Kinase JNK-Activating Protein Kinase JNKK1 Protein Kinase Jun Amino Terminal Kinase Kinase Jun Amino-Terminal Kinase Kinase Kinase, JNKK1 Protein MEK4 Protein Kinase Mitogen Activated Protein Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinase 4 Protein Kinase, JNK-Activating Protein Kinase, JNKK1 Protein Kinase, MEK4 Protein Kinase, SEK1 SAP Kinase Extracellular Signal Regulated Kinase Kinase 1 SAP Kinase Kinase 1 SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 SAPK ERK Kinase 1 SAPK-ERK Kinase 1 SEK1 Protein Kinase Stress Activated Protein Kinase Kinase 1 Stress-Activated Protein Kinase Kinase 1 |
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