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Descriptor English: Mitogen-Activated Protein Kinase Kinases
Descriptor Spanish: Quinasas de Proteína Quinasa Activadas por Mitógenos
Descriptor Portuguese: Quinases de Proteína Quinase Ativadas por Mitógeno
Descriptor French: Mitogen-Activated Protein Kinase Kinases
Entry term(s): Kinase Kinase, Map
Kinase Kinases, MAP
Kinase, MAP-ERK
Kinase, MAPK
Kinase, MAPK-ERK
Kinase, Map Kinase
Kinases, MAP Kinase
Kinases, MAPK
Kinases, MAPK-ERK
MAP ERK Kinase
MAP Kinase Kinases
MAP-ERK Kinase
MAPK ERK Kinase
MAPK ERK Kinases
MAPK Kinase
MAPK Kinases
MAPK-ERK Kinase
MAPK-ERK Kinases
MAPKK
MAPKKs
MEK
MEKs
Map Kinase Kinase
Mitogen Activated Protein Kinase Kinase
Mitogen Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinase Kinase
Tree number(s): D08.811.913.696.620.682.700.565
D08.811.913.696.620.682.725.200
D12.644.360.440
D12.776.476.440
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020929
Scope note: A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.12.2
Previous Indexing: Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
Public MeSH Note: 2000; MAP KINASE KINASE and MAPKK (now MITOGEN-ACTIVATED KINASE KINASES) were indexed under PROTEIN KINASES 1992-1999; MAP-ERK KINASE (now MITOGEN-ACTIVATED KINASE KINASES) was indexed under PROTEIN-TYROSINE KINASE 1992-1999
History Note: 2000; for MAP-ERK KINASE use MEK1 PROTEIN (NM) 1992-1999
Related: MAP Kinase Signaling System MeSH
DeCS ID: 34449
Unique ID: D020929
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/03
Revision Date: 2020/05/27
Mitogen-Activated Protein Kinase Kinases - Preferred
Concept UI M0328038
Scope note A serine-threonine protein kinase family whose members are components in protein kinase cascades activated by diverse stimuli. These MAPK kinases phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES and are themselves phosphorylated by MAP KINASE KINASE KINASES. JNK kinases (also known as SAPK kinases) are a subfamily.
Preferred term Mitogen-Activated Protein Kinase Kinases
Entry term(s) Kinase Kinase, Map
Kinase Kinases, MAP
Kinase, MAPK
Kinase, Map Kinase
Kinases, MAP Kinase
Kinases, MAPK
MAP Kinase Kinases
MAPK Kinase
MAPK Kinases
MAPKK
MAPKKs
Map Kinase Kinase
Mitogen Activated Protein Kinase Kinase
Mitogen Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinase Kinase
MAPK-ERK Kinases - Narrower
Concept UI M0331456
Preferred term MAPK-ERK Kinases
Entry term(s) Kinase, MAP-ERK
Kinase, MAPK-ERK
Kinases, MAPK-ERK
MAP ERK Kinase
MAP-ERK Kinase
MAPK ERK Kinase
MAPK ERK Kinases
MAPK-ERK Kinase
MEK
MEKs



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