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Descriptor English: Diazooxonorleucine
Descriptor Spanish: Diazooxonorleucina
Descriptor diazooxonorleucina
Scope note: Aminoácido que inhibe la gltaminasa activada por fosfato e interfiere con el metabolismo de la glutamina. Es un antibiótico antineoplásico producido por una especie no identificada de Streptomyces del suelo del Perú. (Merck Index, 11th ed)
Descriptor Portuguese: Diazo-Oxo-Norleucina
Descriptor French: 6-Diazo-5-oxo-L-norleucine
Entry term(s): 6 Diazo 5 oxo L norleucine
6-Diazo-5-oxo-L-norleucine
Tree number(s): D02.172.508
D12.125.213.568.175
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003980
Scope note: An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Antimetabolites, Antineoplastic
Registry Number: 03J0H273KZ
CAS Type 1 Name: Norleucine, 6-diazo-5-oxo-
Public MeSH Note: 91; was see under AZO COMPOUNDS 1965-90
History Note: 91(65); was see under AZO COMPOUNDS 1965-90
DeCS ID: 4009
Unique ID: D003980
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Diazooxonorleucine - Preferred
Concept UI M0006241
Scope note An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)
Preferred term Diazooxonorleucine
Entry term(s) 6 Diazo 5 oxo L norleucine
6-Diazo-5-oxo-L-norleucine



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