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Descriptor English: Digoxin
Descriptor Spanish: Digoxina
Descriptor digoxina
Scope note: Glicósido cardiotónico que se obtiene principalmente de la Digitalis lanata. Consta de tres azúcares y de una aglicona, la DIGOXIGENINA. La digoxina tiene actividad inotrópica positiva y cronotrópica negativa. Se usa para controlar la frecuencia ventricular en la FIBRILACIÓN AURICULAR y en el tratamiento de la insuficiencia cardíaca congestiva con fibrilación auricular. Su uso en la insuficiencia cardíaca congestiva con ritmo sinusal está menos comprobado. El margen entre la dosis tóxica y la terapéutica es pequeño. (Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Descriptor Portuguese: Digoxina
Descriptor French: Digoxine
Entry term(s): Boehringer, Digoxina
Digacin
Digitek
Digoregen
Digoxina Boehringer
Digoxine Nativelle
Dilanacin
Hemigoxine Nativelle
Lanacordin
Lanicor
Lanoxicaps
Lanoxin
Lanoxin PG
Lanoxin-PG
Lenoxin
Mapluxin
Nativelle, Digoxine
Nativelle, Hemigoxine
Tree number(s): D04.210.500.155.580.130.500.436
D04.210.500.155.580.130.688
D09.408.180.261.436
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004077
Scope note: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Annotation: do not confuse with DIGITOXIN
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
Registry Number: 73K4184T59
CAS Type 1 Name: Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
DeCS ID: 4116
Unique ID: D004077
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Digoxin - Preferred
Concept UI M0006386
Scope note A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
Preferred term Digoxin
Lanacordin - Narrower
Concept UI M0485081
Preferred term Lanacordin
Lanicor - Narrower
Concept UI M0485080
Preferred term Lanicor
Lanoxicaps - Narrower
Concept UI M0372351
Preferred term Lanoxicaps
Dilanacin - Narrower
Concept UI M0372352
Preferred term Dilanacin
Digacin - Narrower
Concept UI M0485086
Preferred term Digacin
Digitek - Narrower
Concept UI M0485085
Preferred term Digitek
Digoregen - Narrower
Concept UI M0485084
Preferred term Digoregen
Digoxina Boehringer - Narrower
Concept UI M0485083
Preferred term Digoxina Boehringer
Entry term(s) Boehringer, Digoxina
Digoxine Nativelle - Narrower
Concept UI M0485082
Preferred term Digoxine Nativelle
Entry term(s) Hemigoxine Nativelle
Nativelle, Digoxine
Nativelle, Hemigoxine
Mapluxin - Narrower
Concept UI M0485079
Preferred term Mapluxin
Lanoxin - Narrower
Concept UI M0006387
Preferred term Lanoxin
Entry term(s) Lanoxin PG
Lanoxin-PG
Lenoxin



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